The limbic and neocortical contribution of α-synuclein, tau, and amyloid β to disease duration in dementia with Lewy bodies

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Tanis J FermanDennis W Dickson

Abstract

We sought to assess the individual and combined contribution of limbic and neocortical α-synuclein, tau, and amyloid β (Aβ) to duration of illness in dementia with Lewy bodies (DLB). Quantitative digital pathology of limbic and neocortical α-synuclein, tau, and Aβ was assessed in 49 patients with clinically probable DLB. Regression modeling examined the unique and shared contribution of each pathology to the variance of illness duration. Patients with diffuse Lewy body disease had more severe pathology of each type and a shorter duration of illness than individuals with transitional Lewy body disease. The three pathologies accounted for 25% of the total variance of duration of illness, with 19% accounted for by α-synuclein alone or in combination with tau and Aβ. When the diffuse Lewy body disease group was examined separately, α-synuclein deposition significantly exceeded that of tau and Aβ. In this model, 20% of 24% total variance in the model for duration of illness was accounted for independently by α-synuclein. In DLB, α-synuclein is an important predictor of disease duration, both independently and synergistically with tau and Aβ.

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Nov 1, 1993·Journal of Neuropathology and Experimental Neurology·L A HansenR D Terry
Feb 20, 1999·Archives of Neurology·M GearingS S Mirra
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·E MasliahL Mucke
Apr 26, 2003·Science·Benoit I GiassonVirginia M-Y Lee
May 27, 2005·Neurobiology of Aging·Olga PletnikovaJuan C Troncoso
Oct 21, 2005·Neurology·I G McKeithUNKNOWN Consortium on DLB
May 3, 2006·Journal of Neuropathology and Experimental Neurology·V DeramecourtA Delacourte
May 22, 2007·Acta Neurologica Scandinavica·K SikkS-M Aquilonius
Oct 16, 2007·Neuro-degenerative Diseases·Kurt A JellingerKlaus Seppi
Jan 31, 2008·Acta Neuropathologica·Glenda HallidayJohn Morris
Apr 9, 2008·Nature Medicine·Jeffrey H KordowerC Warren Olanow
Jul 4, 2008·Journal of Neuropathology and Experimental Neurology·Hiroshige FujishiroDennis W Dickson
Jul 16, 2008·Acta Neuropathologica·Thomas G BeachCharles H Adler
Oct 9, 2009·Alzheimer Disease and Associated Disorders·Marwan N SabbaghThomas G Beach
Apr 8, 2010·Brain : a Journal of Neurology·Peter A KempsterAndrew J Lees
May 21, 2011·Brain : a Journal of Neurology·Yaroslau ComptaTamas Revesz
Oct 25, 2011·Neurobiology of Aging·Kejal KantarciClifford R Jack
Jul 25, 2012·Archives of Neurology·Paul T KotzbauerJoel S Perlmutter
Oct 6, 2012·Annals of Neurology·David J IrwinJohn Q Trojanowski
Oct 16, 2012·Brain : a Journal of Neurology·J A SchneiderD A Bennett
Nov 14, 2012·Journal of Neuropathology and Experimental Neurology·Janna Hackett NeltnerPeter T Nelson
Mar 8, 2013·Brain : a Journal of Neurology·Masami Masuda-SuzukakeMasato Hasegawa
Jun 12, 2013·Parkinsonism & Related Disorders·Judit HorvathEnikö Kövari
Oct 11, 2013·Nature Communications·Luc BoussetRonald Melki
Nov 15, 2013·Journal of Neuropathology and Experimental Neurology·Martí Colom-CadenaAlberto Lleó

❮ Previous
Next ❯

Citations

Feb 2, 2019·Continuum : Lifelong Learning in Neurology·Melissa J Armstrong
Mar 8, 2018·BMC Medicine·Kurt A Jellinger, Amos D Korczyn
Mar 9, 2019·The Australian and New Zealand Journal of Psychiatry·Kai Sin ChinRosie Watson
Aug 15, 2019·Brain : a Journal of Neurology·Seán O'DowdJohn-Paul Taylor
Oct 30, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·David G CoughlinDavid J Irwin
Nov 7, 2019·Journal of Movement Disorders·Masahito YamadaMitsuhiro Yoshita
Dec 22, 2019·Neurology·Kejal KantarciMelissa E Murray
Feb 6, 2020·Journal of Neurology·Paul C DonaghyJohn T O'Brien
Aug 5, 2020·Translational Psychiatry·Jay AminDelphine Boche
Dec 5, 2020·Acta Neuropathologica Communications·Antonina KouliCaroline H Williams-Gray
Dec 9, 2020·Journal of Alzheimer's Disease : JAD·Thomas G Beach, Michael Malek-Ahmadi
Nov 19, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N G Dudchenko, E E Vasenina
Feb 23, 2021·Journal of Neuropathology and Experimental Neurology·Jodie B NicholsThomas G Beach
May 1, 2021·Journal of Neural Transmission·Kurt A Jellinger
Jun 16, 2021·Neurobiology of Aging·Daniel FerreiraKejal Kantarci
Nov 27, 2021·Seminars in Neurology·Philip W TiptonNeill Graff-Radford
Jan 22, 2022·Annals of Clinical and Translational Neurology·Rebecca L MillerPaul T Kotzbauer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

© 2022 Meta ULC. All rights reserved