PMID: 9181944Dec 1, 1996Paper

The limitation of acute hypotension and hyperactivation of the vascular endothelium in rats with an experimental myocardial infarct by using preliminary adaptation to physical load

Fiziologicheskiĭ zhurnal imeni I.M. Sechenova
E B ManukhinaF Z Meerson

Abstract

Adaptation to swimming exercise was shown to increase the endothelium-dependent relaxation of the rat aorta, leaving the BP unaffected. In experimental myocardial infarction, the adaptation limited the BP fall and completely prevented an excessive suppression of norepinephrine-induced contractions of the aorta. An adaptation to exercise seems to be an efficient protective factor in pathological conditions involving the NO overproduction and endothelial hyperactivation.

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