The Linear No-Threshold Model of Low-Dose Radiogenic Cancer: A Failed Fiction

Dose-response : a Publication of International Hormesis Society
Charles W Pennington, Jeffry A Siegel

Abstract

The linear no-threshold (LNT) model for low-dose, radiogenic cancer has been a fixture of radiation protection and regulatory requirements for decades, but its validity has long been contested. This article finds, yet again, more questionable data and analyses purporting to support the model, this within the "gold-standard" data set for estimating radiation effects in humans. Herein is addressed a number of significant uncertainties in the Radiation Effects Research Foundation's Life Span Study (LSS) cohort of atomic bomb survivors, especially in its latest update of 2017, showing that the study's support of the LNT model is not evidence based. We find that its latest 2 analyses of solid cancer incidence ignore biology and do not support the LNT model. Additionally, we identify data inconsistencies and missing causalities in the LSS data and analyses that place reliance on uncertain, imputed data and apparently flawed modeling, further invalidating the LNT model. These observations lead to a most credible conclusion, one supporting a threshold model for the dose-response relationship between low-dose radiation exposure and radiogenic cancer in humans. Based upon these findings and those cited from others, it becomes apparent th...Continue Reading

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Citations

Oct 1, 2019·Nuclear Medicine Communications·Jim O'Doherty, Pauline Negre
Mar 14, 2020·Health Physics·Hanns Leonhard KaatschBenjamin Valentin Becker
Apr 22, 2020·Dose-response : a Publication of International Hormesis Society·Cara Y KaminskiJoseph M Kaminski
May 20, 2020·Dose-response : a Publication of International Hormesis Society·Paul A Oakley, Deed E Harrison
Mar 23, 2021·Dose-response : a Publication of International Hormesis Society·Paul A Oakley, Deed E Harrison
Apr 7, 2021·Chemico-biological Interactions·Edward J CalabreseWalter J Kozumbo
Apr 30, 2021·European Journal of Nuclear Medicine and Molecular Imaging·An AertsMichael Lassmann
May 27, 2021·Dose-response : a Publication of International Hormesis Society·Maciej PylakLudwik Dobrzyński
Jul 25, 2021·International Journal of Molecular Sciences·Abrar Ul Haq KhanYevgeniya Le

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