The Link between Autoimmunity and Lymphoma: Does NOTCH Signaling Play a Contributing Role?

Frontiers in Oncology
Christina Arieta Kuksin, Lisa M Minter

Abstract

An association between certain autoimmune conditions and increased risk of developing lymphoma is well documented. Recent evidence points to NOTCH signaling as a strong driver of autoimmunity. Furthermore, a role for NOTCH in various lymphomas, including classical Hodgkin lymphoma, non-Hodgkin lymphoma, and T cell lymphoma has also been described. In this mini-review, we will outline what is known about involvement of NOTCH signaling in those autoimmune conditions, such as rheumatoid arthritis and primary Sjörgren's syndrome, which show an increased risk for subsequent diagnosis of lymphoma. Furthermore, we will detail what is known about the lymphomas associated with these autoimmune conditions and how aberrant or sustained NOTCH signaling in the immune cells that mediate these diseases may contribute to lymphoma.

References

Dec 15, 2000·International Journal of Molecular Medicine·M NakazawaT Nakajima
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Diana BellaviaIsabella Screpanti
Jan 28, 2003·Journal of Cellular Physiology·Tatsuya IsoYasuo Hamamori
Nov 5, 2003·The Journal of Pathology·Florian EmmerichBernd Dörken
Jun 17, 2004·British Journal of Haematology·Roman K ThomasRoland Schmitz
Nov 25, 2005·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Yoshihiro YabeHiroyuki Shindo
Aug 29, 2006·Leukemia Research·Raffaella Chiaramonte
May 8, 2007·International Journal of Hematology·Daisuke ShimizuMasafumi Taniwaki
Oct 11, 2007·Blood·David T TeacheyStephan A Grupp
Feb 22, 2008·Current Molecular Medicine·Franziska JundtBernd Dörken
May 23, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Stephen D MarksNeil J Sebire
May 30, 2008·Haematologica·Gunhild TrøenJan Delabie
Mar 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laëtitia Le PottierJacques-Olivier Pers
Mar 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mika KijimaKoji Yasutomo
Apr 15, 2009·International Journal of Cancer. Journal International Du Cancer·Lesley A AndersonEric A Engels
Apr 22, 2009·Cell·Raphael Kopan, Maria Xenia G Ilagan
Feb 16, 2010·Immunity·Freddy RadtkeH Robson Macdonald
Apr 30, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Weijuan ZhangSidong Xiong
Feb 18, 2011·Genes and Immunity·S L MusoneL A Criswell
Apr 8, 2011·Journal of Human Genetics·Vinod KumarKoichi Matsuda

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Citations

Jul 28, 2015·Current Medical Research and Opinion·Magali Van den BerghConstantin A Dasanu
Dec 6, 2017·International Journal of Rheumatic Diseases·Yu-Hsuan ShihChieh-Lin Jerry Teng
Oct 30, 2020·Journal of Clinical Medicine·Pierluigi MasciopintoFrancesco Albano

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Methods Mentioned

BETA
nuclear translocation
biopsies

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