The Link between Psychological Stress and Autoimmune Response in Children

Critical Reviews in Immunology
Maria Faresjö

Abstract

Stress is defined as a state of threatened homeostasis or disharmony that is counteracted by a complex repertoire of physiological and behavioral adaptive responses in order to establish homeostasis. Confronted with a stressful condition, the nervous and immune systems initiate a coping process to maintain homeostasis in the body. Psychological stress, recognized as a public health issue in children and young adults, may be one mechanism to induce and maintain autoimmunity in children. It is necessary to increase our understanding of how psychological stress can affect the immune system at a young age because autoimmune diseases, especially type 1 diabetes, are alarmingly common in children. Psychological stress may be involved in other autoimmune diseases, such as celiac disease, systemic lupus erythematosus, and juvenile idiopathic arthritis, that frequently occur in children as well. This review summarizes the studies attempting to evaluate the link between psychological stress and autoimmune response in children. A number of them have observed that the autoimmune disease itself causes psychological stress. We are far from fully understanding how long-term psychological stress is linked to autoimmune response in children wit...Continue Reading

Citations

Feb 16, 2019·Stress and Health : Journal of the International Society for the Investigation of Stress·Roswith RothUNKNOWN TEDDY Study Group
Dec 21, 2019·Pediatric Rheumatology Online Journal·Alexandra Dimitrijevic CarlssonPer Alstergren
Nov 21, 2019·Pediatric Diabetes·Santhi N LogelJennifer L Rehm
Sep 19, 2019·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Ciara Jade Bansal, Amolak Singh Bansal
May 13, 2018·Acta Diabetologica·Markus LundgrenUNKNOWN DiPiS study group
Nov 2, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Stefanie BraigJon Genuneit
Sep 28, 2018·Environmental Pollution·Payam DadvandRoya Kelishadi

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