The link "Cancer and autoimmune diseases" in the light of microbiota: Evidence of a potential culprit.

Immunology Letters
Elena NiccolaiAmedeo Amedei

Abstract

Evidence establishes that chronic inflammation and autoimmunity are associated with cancer development and patients with a primary malignancy may develop autoimmune-like diseases. Despite immune dysregulation is a common feature of both cancer and autoimmune diseases, precise mechanisms underlying this susceptibility are not clarified and different hypotheses have been proposed, starting from genetic and environmental common features, to intrinsic properties of immune system. Moreover, as the development and use of immunomodulatory therapies for cancer and autoimmune diseases are increasing, the elucidation of this relationship must be investigated in order to offer the best and most secure therapeutic options. The microbiota could represent a potential link between autoimmune diseases and cancer. The immunomodulation role of microbiota is widely recognized and under eubiosis, it orchestrates both the innate and adaptive response of immunity, in order to discriminate and modulate the immune response itself in the most appropriate way. Therefore, a dysbiotic status can alter the immune tonus rendering the host prone to exogenous or endogenous infections, breaking the tolerance against self-components and activating the immune re...Continue Reading

References

Dec 1, 1976·Journal of the National Cancer Institute·M R Sacksteder
Nov 18, 1989·BMJ : British Medical Journal·D P Strachan
Oct 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·G D Abrams, J E Bishop
Jan 15, 1981·The New England Journal of Medicine·N Gutensohn, P Cole
Jan 1, 1981·Annual Review of Nutrition·B S Wostmann
Jun 1, 1995·Lupus·D P Symmons
May 8, 1999·The American Journal of Clinical Nutrition·J J Cebra
Oct 21, 1999·The New England Journal of Medicine·T SakaneG Inaba
Jun 3, 2000·Annual Review of Immunology·M Karin, Y Ben-Neriah
Apr 4, 2001·Rheumatology·T M LawsonB D Williams
Jan 10, 2002·Gastroenterology·Alexander SwidsinskiHerbert Lochs
Jan 12, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shuji MatsumuraM Eric Gershwin
Aug 21, 2002·The Journal of Experimental Medicine·Marika C KullbergAlan Sher
Jan 7, 2003·The Journal of Biological Chemistry·Naohiro InoharaGabriel Nuñez
Jun 5, 2003·Current Molecular Medicine·Tsuneyasu Kaisho, Shizuo Akira
Oct 3, 2003·International Journal of Dermatology·Gülsevim AzizlerliRian Dişçi
Oct 22, 2003·The Journal of Experimental Medicine·Amedeo AmedeiGianfranco Del Prete
Dec 3, 2003·Trends in Immunology·Stephen E GirardinPhilippe J Sansonetti
Dec 20, 2003·Gut·C P TamboliJ F Colombel
Jan 7, 2004·Nature Reviews. Cancer·Glenn Dranoff
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hua YangDaniel H Teitelbaum
Jun 3, 2004·Nature Reviews. Immunology·Andrew J Macpherson, Nicola L Harris
Nov 2, 2004·European Journal of Immunology·Lars HelgelandJohn Torgils Vaage
Nov 24, 2004·Clinical & Developmental Immunology·Zhonghui Wen, Claudio Fiocchi
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia Di GiacintoMonica Boirivant
Apr 30, 2005·Immunology Letters·Hidenori TakahashiHidetada Sasaki
Apr 30, 2005·Journal of Pediatric Gastroenterology and Nutrition·Josef NeuMark Atkinson
May 18, 2005·The Journal of Experimental Medicine·Jonathan SamuelsEric Meffre
Jan 6, 2006·The American Journal of Gastroenterology·Tine JessThorkild I A Sørensen
Mar 18, 2006·The Journal of Clinical Investigation·Amedeo AmedeiMarina de Bernard
Jun 8, 2006·Journal of Clinical Microbiology·Fred C Westall
Aug 26, 2006·Science·Heather L CashLora V Hooper
Aug 26, 2006·Nature Clinical Practice. Rheumatology·Lars KlareskogLars Alfredsson

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Citations

Jan 12, 2021·Frontiers in Pharmacology·Cinzia Parolini, Amedeo Amedei

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