Feb 24, 2019

The Linked Selection Signature of Rapid Adaptation in Temporal Genomic Data

BioRxiv : the Preprint Server for Biology
Vince Buffalo, Graham Coop

Abstract

The majority of empirical population genetic studies have tried to understand the evolutionary processes that have shaped genetic variation in a single sample taken from a present-day population. However, genomic data collected over tens of generations in both natural and lab populations are increasingly used to find selected loci underpinning adaptation over these short timescales. Although these studies have been quite successful in detecting selection on large-effect loci, the fitness differences between individuals are often polygenic, such that selection leads to allele frequency changes that are difficult to distinguish from genetic drift. However, one promising signal comes from polygenic selection's effect on neutral sites that become stochastically associated with the genetic backgrounds that lead to fitness differences between individuals. Previous theoretic work has established that the random associations between a neutral allele and heritable fitness backgrounds act to reduce effective population experienced by this neutral allele (Santiago and Caballero, 1995, 1998). These associations perturb neutral allele frequency trajectories, creating autocovariance in the allele frequency changes across generations. Here, w...Continue Reading

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Mentioned in this Paper

Genetic Drift
Genome
Genome Assembly Sequence
Recombination, Genetic
Genomics
Adaptation
Genetic Studies
Locus
Alleles
Orientation (spatial)

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