The linker between LOV2-Jα and STK plays an essential role in the kinase activation by blue light in Arabidopsis phototropin1, a plant blue light receptor

FEBS Letters
Sachiko KashojiyaSatoru Tokutomi

Abstract

Phototropin (phot), a blue light receptor in plants, is composed of several domains: LOV1, LOV2, and a serine/threonine kinase (STK). LOV2 is the main regulator of light activation of STK. However, the detailed mechanism remains unclear. In this report, we focused on the linker region between LOV2 and STK excluding the Jα-helix. Spectroscopy and a kinase assay for the substituents in the linker region of Arabidopsis phot1 LOV2-STK indicated that the linker is involved in the activation of STK. A putative module in the middle of the linker would be critical for intramolecular signaling and/or regulation of STK.

References

Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·S Crosson, K Moffat
May 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SakaiK Okada
Jul 10, 2001·The Journal of Biological Chemistry·T E SwartzR A Bogomolni
Dec 12, 2001·Nature·T KinoshitaK Shimazaki
Mar 14, 2002·Current Opinion in Cell Biology·Peter H Quail
Oct 18, 2002·The Plant Journal : for Cell and Molecular Biology·John M ChristieWinslow R Briggs
Sep 13, 2003·Science·Shannon M HarperKevin H Gardner
Mar 18, 2004·Journal of the American Chemical Society·Shannon M HarperKevin H Gardner
Dec 22, 2004·Biochemistry·Shannon M HarperKevin H Gardner
Oct 28, 2006·Annual Review of Plant Biology·John M Christie
Jul 10, 2007·Journal of Molecular Biology·Takeshi EitokuMasahide Terazima
Jul 31, 2007·The Plant Journal : for Cell and Molecular Biology·Sam-Geun KongAkira Nagatani
Nov 9, 2007·Biochimica Et Biophysica Acta·Satoru TokutomiKazunori Zikihara
Jul 1, 2008·Journal of Molecular Biology·Masayoshi NakasakoSatoru Tokutomi
Jan 27, 2009·FEBS Letters·Hitomi KatsuraSatoru Tokutomi
Aug 9, 2011·Nature Reviews. Microbiology·Julien Herrou, Sean Crosson
Jul 12, 2012·The EMBO Journal·Emilie DemarsyChristian Fankhauser
Sep 21, 2012·Nature Reviews. Molecular Cell Biology·Susan S TaylorAlexandr P Kornev
Jul 3, 2013·Nature Communications·Atsushi TakemiyaKen-ichiro Shimazaki
Jul 3, 2013·Molecular BioSystems·Jeroen B van der SteenKlaas J Hellingwerf
Dec 10, 2013·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Andrei S Halavaty, Keith Moffat
Dec 4, 2014·Proceedings of the National Academy of Sciences of the United States of America·Giomar Rivera-CancelKevin H Gardner
May 8, 2015·Nature Protocols·Lawrence A KelleyMichael J E Sternberg

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Citations

Jan 28, 2016·Journal of Plant Research·Koji Okajima
Apr 8, 2017·The Journal of Physical Chemistry. B·Akira TakakadoMasahide Terazima
Sep 16, 2020·International Journal of Molecular Sciences·Masayoshi NakasakoKoji Okajima
Mar 31, 2021·The Journal of Biological Chemistry·Jaynee E Hart, Kevin H Gardner

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