The Linoleic Acid: Dihomo-γ-Linolenic Acid Ratio (LA:DGLA)-An Emerging Biomarker of Zn Status

Marija KnezElad Tako


Zinc (Zn) deficiency is a common aliment predicted to affect 17% of the world's population. Zinc is a vital micronutrient used for over 300 enzymatic reactions and multiple biochemical and structural processes in the body. Although whole blood, plasma, and urine zinc decrease in severe zinc deficiency, accurate assessment of zinc status, especially in mild to moderate deficiency, is difficult as studies with these biomarkers are often contradictory and inconsistent. Hence, as suggested by the World Health Organization, sensitive and specific biological markers of zinc status are still needed. In this review, we provide evidence to demonstrate that the LA:DGLA ratio (linoleic acid:dihomo-γ-linolenic acid ratio) may be a useful additional indicator for assessing Zn status more precisely. However, this biomarker needs to be tested further in order to determine its full potential.


Aug 1, 1976·Biochemical Pharmacology·M ChvapilR L Misiorowski
Mar 1, 1979·The Journal of Nutrition·W J BettgerB L O'Dell
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B L Scott, N G Bazan
Sep 1, 1981·Medical Hypotheses·D F Horrobin
Dec 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·S C CunnaneM S Manku
Mar 1, 1982·Clinical and Experimental Pharmacology & Physiology·A A Odutuga
Apr 1, 1980·Chemico-biological Interactions·J C LudwigM D Seymour
Jan 1, 1993·Physiological Reviews·B L Vallee, K H Falchuk
Apr 1, 1993·The American Journal of Clinical Nutrition·P E JohnsonL K Mullen
Mar 1, 1996·The American Journal of Clinical Nutrition·L SianK M Hambidge
Aug 1, 1996·Biological Trace Element Research·K Eder, M Kirchgessner
Oct 10, 1998·Biochimica Et Biophysica Acta·D A Los, N Murata
Dec 29, 1998·The Journal of Biological Chemistry·H P ChoS D Clarke
May 10, 2000·The Journal of Nutrition·J C KingL R Woodhouse
Aug 10, 2000·Journal of Child and Adolescent Psychopharmacology·L E ArnoldN Votolato
Jul 18, 2001·Journal of Experimental Botany·O SayanovaJ A Napier
Jun 11, 2004·Annual Review of Nutrition·Manabu T Nakamura, Takayuki Y Nara
Dec 30, 2004·Nutrition Reviews·Penny M Kris-EthertonAmy E Binkoski
Jun 24, 2006·The Journal of Biological Chemistry·Robert J CousinsLouis A Lichten
Nov 8, 2006·Molecular Microbiology·Pablo S Aguilar, Diego de Mendoza
May 8, 2009·The American Journal of Clinical Nutrition·Nicola M LoweTamás Decsi
Sep 16, 2009·Annals of Nutrition & Metabolism·W M Nimal Ratnayake, Claudio Galli
Sep 24, 2011·Mutation Research·Razinah SharifMichael Fenech
Jun 6, 2012·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ananda S Prasad
Aug 21, 2013·Critical Reviews in Food Science and Nutrition·Nicola M LoweVictoria Hall-Moran

❮ Previous
Next ❯


Aug 15, 2019·Metallomics : Integrated Biometal Science·Rebekah E T MooreFiona Larner
Sep 6, 2018·The Journal of Nutrition·Janet C King
Nov 23, 2019·Nutrients·Elad Tako
May 27, 2021·The Journal of Nutrition·Erinn M LiongJanet C King

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.