PMID: 7528469Jan 1, 1995Paper

The lipase to amylase ratio in acute pancreatitis

The American Journal of Gastroenterology
L G KingJ E Ranney

Abstract

The ratio of serum lipase to serum amylase has been proposed to distinguish acute episodes of alcoholic from nonalcoholic pancreatitis. We evaluated the efficacy of this test in a community hospital setting. Charts of all patients discharged with a diagnosis of acute pancreatitis over 19 months were retrospectively reviewed. Patients were excluded if their creatinine was greater than 3.0 mg/dl, if the amylase and lipase were not measured within 72 h of the onset of symptoms, or if the cause of pancreatitis was not known by the time of discharge. Of the 56 patients, 31 had alcoholic pancreatitis. The lipase to amylase ratio did not differ significantly between patients with alcoholic and nonalcoholic pancreatitis. Median amylase and lipase were significantly higher in nonalcoholic pancreatitis; however, the wide ranges of both meant that neither amylase nor lipase accurately determined the cause of pancreatitis. The lipase to amylase ratio does not appear to be sufficiently sensitive or specific to distinguish alcoholic from nonalcoholic acute pancreatitis.

Citations

Dec 14, 1999·The Journal of Emergency Medicine·R J VissersD F McHugh
Mar 29, 2006·Journal of Clinical Pathology·W R MatullJ W O'Donohue
Oct 1, 2009·Indian Journal of Clinical Biochemistry : IJCB·Anitha Devanath Arokiasami
Jun 23, 2001·The American Journal of Gastroenterology·J R AparicioM Pérez-Mateo
Apr 22, 2017·The Cochrane Database of Systematic Reviews·Gianluca RompianesiKurinchi Selvan Gurusamy
Apr 1, 1998·Addiction Biology·M V ApteJ S Wilson
May 11, 2016·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·John S BarbieriRebecca Jaffe

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