PMID: 11341371May 9, 2001Paper

The lipid-lowering effect of trans-dehydrocrotonin, a clerodane diterpene from Croton cajucara Benth. in mice fed on high-fat diet

The Journal of Pharmacy and Pharmacology
Regilane M SilvaA C Pinto

Abstract

The clerodane diterpene trans-dehydrocrotonin extracted and isolated from the stem bark of Croton cajucara Benth. was investigated for its lipid-lowering effect in mice fed on a high-fat diet. Mice fed on a high-fat diet for a two-week period demonstrated significantly increased blood levels of total cholesterol and triglycerides, compared with normal controls. Oral treatment with trans-dehydrocrotonin at a dose of 25 or 50 mg kg(-1) daily markedly suppressed the high-fat-diet associated rise in total cholesterol and triglyceride levels. The hypocholesterolaemic effect of trans-dehydrocrotonin was more prominent at the dose of 50 mg kg(-1) with significant decreases in high-density lipoprotein, very-low-density lipoprotein and low-density lipoprotein cholesterol levels. The lower atherogenic index of the trans-dehydrocrotonin-treated groups suggests the hypolipidaemic potential of this plant-based drug. These results indicate that orally administered trans-dehydrocrotonin is effective in suppressing high-fat-diet-induced hyperlipidaemia in mice and suggest its likely beneficial use as anti-atherogenic agent.

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Citations

Dec 6, 2012·Chinese Journal of Integrative Medicine·Kaladevi Siddhi VinayagamSachdanandam Panchanatham
May 23, 2003·Antimicrobial Agents and Chemotherapy·Maria do Socorro S do Socorro S RosaAngela Hampshire C S Lopes
Sep 24, 2004·Canadian Journal of Physiology and Pharmacology·Eliete J B BighettiHelena C F Oliveira
Jun 25, 2005·Vascular Pharmacology·Regilane M SilvaVietla S N Rao
Jan 22, 2019·Natural Product Research·Agata KoziołStanisław Lochyński

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