The lipofuscin-iron association in pigmentosis tubae

Ultrastructural Pathology
M MunichorT C Iancu

Abstract

Pigmentosis tubae (PT) is a rare condition characterized by the presence of numerous lipofuscin-laden macrophages in the lamina propria of the fallopian tube. Two women, who also had endometriotic ovarian cysts, showed polypoid pigmented tubal mucosae. In addition to lipofuscin, occasional cells showed spotty positivity for iron. Ultrastructural examination of the tubal mucosa showed the lipofuscin-containing bodies, which were similar to lipofuscin-containing lysosomes found in other pigmented conditions. Cytoplasmatic ferritin and hemosiderin in siderosomes were observed in macrophages and endothelial cells of the lamina propria. The present study is the first to demonstrate the presence of iron-containing particles and lipofuscin in the residual bodies of PT. The origin of the excess iron is not clear, but erythrophagocytosis and an abnormal tubal environment could play a role. Iron-promoted lipid peroxidation may alter the lysosomal membranes and contribute to the excessive accumulation of lipofuscin in these cells.

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Citations

Jan 10, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Mitsuko FuruyaTakashi Yoshiki
Mar 6, 2018·The American Journal of Surgical Pathology·Kelly J Butnor, Jamen R Bartlett
Apr 22, 2010·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Maria Grazia ZorziFrancesco Piscioli
Nov 14, 1997·Ultrastructural Pathology·H J Sobel
Mar 12, 2015·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Jeffrey D Seidman, Renee Woodburn
Dec 17, 2020·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Tien Anh N Tran, Robert W Holloway
Apr 10, 2003·Archives of Pathology & Laboratory Medicine·Antonio E Martinez, Robert J Poppiti

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