PMID: 9434140Jan 20, 1998Paper

The lipolysis of chylomicrons derived from different dietary fats by lipoprotein lipase in vitro

Biochimica Et Biophysica Acta
K M BothamE Bravo

Abstract

The lipolysis of chylomicrons derived from palm, olive, corn or fish oil (enriched in saturated, monounsaturated, n - 6 polyunsaturated and n - 3 polyunsaturated fatty acids, respectively) by rat post-heparin lipoprotein lipase in vitro was compared by measuring the release of [3H]oleate from their triacylglycerol. Chylomicrons derived from corn oil were lipolysed more rapidly than the other types in the first 20 min of the reaction, but after 120 min the total amount of triacylglycerol hydrolysed was similar with all types of chylomicrons used. The rate of lipolysis of the different types of chylomicrons also showed different dependencies on the substrate concentration. The highest Vmax values were obtained when the chylomicrons were derived from olive and corn oil and the lowest when they were derived from palm oil, while olive oil chylomicrons gave the highest Km and palm oil chylomicrons the lowest. These results indicate that differential metabolism of chylomicrons of different fatty acid composition by lipoprotein lipase may play a part in the differential rates of clearance from the blood of lipid of dietary origin demonstrated in earlier work from our laboratory.

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Citations

Feb 11, 2009·Archives of Internal Medicine·Erik IngelssonSander J Robins
Apr 6, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·E N MaldonadoM I Aveldaño
Oct 12, 2013·Journal of Animal Physiology and Animal Nutrition·K KayaT Güldür
Apr 22, 2017·Biochimica Et Biophysica Acta. Biomembranes·Javier S Perona
Feb 7, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sandra Jimena Hernández VallejoJean-Marc Lacorte
Dec 10, 1999·Canadian Journal of Physiology and Pharmacology·R Levy, G R Herzberg
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·Carine BeysenKeith N Frayn
May 31, 2013·The American Journal of Clinical Nutrition·André J TremblayPatrick Couture
Oct 28, 1999·The Journal of Nutrition·G AssetJ Dallongeville
Nov 26, 1999·The Journal of Nutrition·R AbiaV Ruiz-Gutiérrez
May 10, 2020·The British Journal of Nutrition·Thalita Lin Netto CândidoRita de Cássia Gonçalves Alfenas
Jan 28, 2005·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M NapolitanoR Rivabene

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