PMID: 9645504Jun 30, 1998Paper

The lipolysis stimulated receptor: a gene at last

Current Opinion in Lipidology
B E Bihain, F T Yen

Abstract

The lipolysis stimulated receptor is a lipoprotein receptor that was initially described in 1992. In the presence of free fatty acids, the lipolysis stimulated receptor recognizes either apolipoprotein B or apolipoprotein E, and as a consequence, leads to the internalization and degradation of the lipoprotein particles. Its affinity is highest for those lipoproteins most susceptible to lipolysis, triglyceride-rich lipoproteins. Since the initial biochemical identification and description of the lipolysis stimulated receptor, several reports have been published by our group that provide circumstantial evidence for its role in vivo for the clearance of triglyceride-rich lipid particles. In this review, we bring the readers up-to-date on the evidence for the role of the lipolysis stimulated receptor in lipoprotein metabolism, as well as the recent developments in its molecular characterization.

References

Apr 1, 1988·Clinical Biochemistry·M HuettingerH Goldenberg
Apr 4, 1986·Science·M S Brown, J L Goldstein
Jul 21, 1995·The Journal of Biological Chemistry·A A TroussardF T Yen
Jul 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·M M HussainT L Innerarity

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Citations

Sep 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Panagiotis PapatheodorouKlaus Aktories
Jan 19, 2012·Infection and Immunity·Panagiotis PapatheodorouKlaus Aktories
Dec 14, 2007·Pharmacogenetics and Genomics·Mikael OscarsonUrs A Meyer
May 1, 1999·The Journal of Biological Chemistry·F T YenB E Bihain
Jul 9, 2016·Oncotarget·Bernd A CzulkiesPanagiotis Papatheodorou

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