The lipopolysaccharide O side chain of Vibrio vulnificus serogroup E is a virulence determinant for eels.

Infection and Immunity
C AmaroR Collado

Abstract

Vibrio vulnificus is a gram-negative bacterium capable of producing septicemic infections in eels and immunocompromised humans. Two biotypes are classically recognized, with the virulence for eels being specific to strains belonging to biotype 2, which constitutes a homogeneous lipopolysaccharide (LPS)-based O serogroup (which we have designated serogroup E). In the present study we demonstrated that the O side chain of this LPS determines the selective virulence of biotype 2 for eels: (i) biotype 1 strains (which do not belong to serogroup E) are destroyed by the bactericidal action of nonimmune eel serum (NIS) through activation of the alternative pathway of complement, (ii) biotype 2 strains (of serogroup E) are resistant to NIS, and (iii) rough mutants of biotype 2 lacking the O polysaccharide side chain are sensitive to NIS and avirulent for eels.

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Citations

Jan 30, 2015·Environmental Microbiology·David PajueloCarmen Amaro
Mar 29, 2020·Environmental Microbiology·Daniel OyanedelDelphine Destoumieux-Garzón
Mar 2, 1999·Applied and Environmental Microbiology·C AmaroE Alcaide
Dec 3, 1998·Applied and Environmental Microbiology·L HøiA Dalsgaard
Jun 18, 2019·Environmental Microbiology·Carla Hernández-CabanyeroCarmen Amaro
Apr 17, 2020·Frontiers in Microbiology·Carla Hernández-CabanyeroCarmen Amaro
Aug 27, 2002·Fish & Shellfish Immunology·M Claire H Holland, John D Lambris
Jul 28, 2004·Fish & Shellfish Immunology·M Dolores Esteve-Gassent, Carmen Amaro

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