The lipoprotein lipase activity of brown adipose tissue during early post-natal development of the normal and hypothyroid rat

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
P HemonG Mory

Abstract

The heparin-releasable LP lipase activity of BAT (brown adipose tissue), and the TG (triglyceride) content of plasma were determined in normal and hypothyroid rats during early post-natal development. The TG content of plasma increased sharply after the onset of suckling and decreased during the weaning period in normal rats, while it stayed at a high level in hypothyroid rats. LP lipase activity was maximal during the perinatal period and decreased later, being practically undetectable in one month old control animals; in contrast, LP lipase activity was still present in cretin rats at this age. The effects of several forms of treatment were also tested in weaned rats: a high-fat diet was not able to maintain the high LP lipase activity of suckling rats, but the activity was high if the animals were bred at a cold temperature. Thyroxine injections had no effect. These results are discussed in terms of the possible factors regulating the LP lipase activity in BAT.

Citations

Mar 1, 1983·Biochimica Et Biophysica Acta·N SkottováG Bengtsson
Sep 1, 1976·Lipids·F J Zeman, M L Fratzke
Jan 1, 1981·The International Journal of Biochemistry·A Cryer
Nov 1, 1984·Clinics in Endocrinology and Metabolism·D Ricquier, G Mory
May 1, 1989·The American Journal of Physiology·C M Carneheim, S E Alexson

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