PMID: 6403364Mar 1, 1983Paper

The lipoprotein profile and phospholipase activity of subretinal fluid

Experimental Eye Research
D O GebhardtM Post

Abstract

We have studied the lipoprotein profile of subretinal fluid by crossed immunoelectrophoresis using an antiserum against apolipoprotein A-I. If the detachment had occurred recently, we found that the subretinal fluid contained only the alpha 1-lipoprotein of serum. However, if the detachment was of longer duration an increasing amount of an electrophoretically slower-moving lipoprotein was also present in the subretinal fluid. We present evidence that subretinal fluid contains an enzyme, phospholipase A, which can form the slower-moving component from alpha 1-lipoprotein. Since the retina has a high phospholipid content, permanent damage may be caused to its structure by the action of this hydrolysing enzyme.

References

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Citations

Aug 1, 1993·International Ophthalmology·V HuervaA Palomar
Jan 29, 2000·European Journal of Ophthalmology·G Malukiewicz-Wiśniewska, M Kotschy
Feb 1, 2002·European Journal of Ophthalmology·G Malukiewicz-Wiśniewska, M Kotschy

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