PMID: 2479248Jan 1, 1989Paper

[The liver--an immunologically privileged organ?].

Allergie und Immunologie
H Jahr, H Wolff

Abstract

Some rat strains permanently accept allogenic livers without pharmacological immune suppression. In the same donor/recipient combinations, other organs as heart, kidney or skin are normally rejected. The transplanted liver not only withstands its own rejection, but also induce donor-specific immune tolerance. The mechanisms responsible for this effect may be clonal deletion, activation of suppressor cells or immune suppressive circulating factors as anti-class II-antibodies. An "immune-privilege" of an orthotopically transplanted liver exists also in pigs and, however to a lesser extent, in other large mammalian species including man. Regeneration of liver tissue altered by the transplantation procedure may produce the signals for induction of tolerogenic mechanisms.

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