The Liver Protection Effects of Maltol, a Flavoring Agent, on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Inhibiting Apoptosis and Inflammatory Response

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Wei LiuWei Li

Abstract

The purpose of this research was to evaluate whether maltol could protect from hepatic injury induced by carbon tetrachloride (CCl₄) in vivo by inhibition of apoptosis and inflammatory responses. In this work, maltol was administered at a level of 100 mg/kg for 15 days prior to exposure to a single injection of CCl₄ (0.25%, i.p.). The results clearly indicated that the intrapulmonary injection of CCl₄ resulted in a sharp increase in serum aspartate transaminase (AST) and alanine transaminase (ALT) activities, tumor necrosis factor-α (TNF-α), irreducible nitric oxide synthase (iNOS), nuclear factor-kappa B (NF-κB) and interleukin-1β (IL-1β) levels. Histopathological examination demonstrated severe hepatocyte necrosis and the destruction of architecture in liver lesions. Immunohistochemical staining and western blot analysis suggested an accumulation of iNOS, NF-κB, IL-1β and TNF-α expression. Maltol, when administered to mice for 15 days, can significantly improve these deleterious changes. In addition, TUNEL and Hoechst 33258 staining showed that a liver cell nucleus of a model group diffused uniform fluorescence following CCl₄ injection. Maltol pretreatment groups did not show significant cell nuclear condensation and fragment...Continue Reading

References

Jan 1, 1989·Pharmacology & Therapeutics·R O RecknagelR L Waller
Apr 6, 2006·Journal of Biochemistry and Molecular Biology·Yang YangZinan Zhang
Aug 25, 2007·Journal of Gastroenterology and Hepatology·Etsuro Hatano
Oct 30, 2007·Journal of Applied Toxicology : JAT·Pablo Muriel, Yadira Rivera-Espinoza
Apr 3, 2008·The Journal of Pharmacy and Pharmacology·Ki Sung KangTakako Yokozawa
Jul 27, 2011·Environmental Toxicology and Pharmacology·Jie-Qiong MaYun-Zhi Sun
Sep 22, 2012·Trends in Cell Biology·Laura TornatoreGuido Franzoso
Nov 16, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Éva A EnyedyBernhard K Keppler
Nov 26, 2015·Expert Opinion on Pharmacotherapy·Andreas Stallmach, Carsten Büning
Jan 11, 2017·Oxidative Medicine and Cellular Longevity·Sha LiYibin Feng
Mar 6, 2017·BMC Complementary and Alternative Medicine·Jen-Chieh TsaiWen-Huang Peng
Oct 13, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Zhi-Na MaWei Li
Mar 25, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mousa O GermoushAyman M Mahmoud
Apr 2, 2018·Journal of Dairy Science·Alberto R CorrochanoLinda Giblin
May 3, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wei WangWeizhe Jiang
May 12, 2018·The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology·Muhammad Amjad PervezShamrez Khan
Jun 2, 2018·Mediators of Inflammation·Mariana Mendes-Braz, Joilson O Martins
Jun 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rongshuang YuanChunmei Wang
Jun 19, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ulas AcarozKui Zhu

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Citations

Nov 20, 2020·Journal of Cellular and Molecular Medicine·Hongwei LuHaidong Jin
May 16, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Li-Wei WangChao-Mei Ma
Dec 18, 2021·Drug and Chemical Toxicology·Nayeon YangTaekyun Shin

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
light microscopy

Software Mentioned

Pro plus
Image
GraphPad Prism
Quantity One
Ridit

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