The Living Scar--Cardiac Fibroblasts and the Injured Heart

Trends in Molecular Medicine
Eva A Rog-ZielinskaRoger Markwald

Abstract

Cardiac scars, often dubbed 'dead tissue', are very much alive, with heterocellular activity contributing to the maintenance of structural and mechanical integrity following heart injury. To form a scar, non-myocytes such as fibroblasts are recruited from intra- and extra-cardiac sources. Fibroblasts perform important autocrine and paracrine signaling functions. They also establish mechanical and, as is increasingly evident, electrical junctions with other cells. While fibroblasts were previously thought to act simply as electrical insulators, they may be electrically connected among themselves and, under some circumstances, to other cells including cardiomyocytes. A better understanding of these biophysical interactions will help to target scar structure and function, and will facilitate the development of novel therapies aimed at modifying scar properties for patient benefit.

References

Jun 1, 1992·Journal of Molecular and Cellular Cardiology·A M De MazièreL N Bouman
May 1, 1989·Pflügers Archiv : European journal of physiology·M B RookB de Jonge
Apr 1, 1972·The Journal of Experimental Medicine·G GabbianiG Majno
Sep 1, 1994·Clinical Immunology and Immunopathology·K M FriesR P Phipps
Jan 1, 1997·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·P C LekicC A McCulloch
Apr 3, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·L I Smith-Mungo, H M Kagan
Mar 10, 1999·Progress in Biophysics and Molecular Biology·P KohlD Noble
Apr 25, 2000·Cardiovascular Research·Y Sun, K T Weber
May 4, 2002·Nature Reviews. Molecular Cell Biology·James J TomasekRobert A Brown
Aug 30, 2002·Basic Research in Cardiology·Yao SunKarl T Weber
Feb 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Oliver DewaldMark L Entman
Aug 2, 2003·Circulation Research·Giedrius GaudesiusStephan Rohr
Oct 29, 2003·Current Opinion in Biotechnology·Boris Hinz, Giulio Gabbiani
Nov 25, 2003·The American Journal of Pathology·Jitka Ismail Virag, Charles E Murry
Feb 14, 2004·Science·Amin RustomHans-Hermann Gerdes
Apr 20, 2004·Cardiovascular Research·Patrizia CamellitiColin R Green
Jun 29, 2004·Histochemistry and Cell Biology·Helene M LangevinDouglas J Taatjes
Jul 16, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Edie C GoldsmithThomas K Borg
Dec 29, 2004·Cardiovascular Research·Patrizia CamellitiPeter Kohl
Mar 17, 2005·Cardiovascular Research·Georg Ertl, Stefan Frantz
Jul 7, 2005·The Journal of Thoracic and Cardiovascular Surgery·Alfred HagerJohn Hess
Sep 20, 2005·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Toshiyuki YanoKazuaki Shimamoto
Sep 20, 2005·Immunity·Simon C Watkins, Russell D Salter
Oct 18, 2005·Journal of Electrocardiology·Peter KohlGodfrey L Smith
Jul 21, 2006·Cardiovascular Research·Helge MöllmannAlbrecht Elsässer
Nov 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Sandra B HaudekMark L Entman
Nov 30, 2006·Annals of the New York Academy of Sciences·Richard P Visconti, Roger R Markwald
Jan 18, 2007·Journal of Cellular Biochemistry·Russell A NorrisRoger R Markwald
Feb 15, 2007·The Journal of Investigative Dermatology·Boris Hinz
May 5, 2007·Thrombosis and Haemostasis·Nikolaos G Frangogiannis

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Citations

Jan 18, 2016·Journal of Molecular and Cellular Cardiology·Emily Ongstad, Peter Kohl
Jun 25, 2016·Nature Reviews. Drug Discovery·Robert G GourdiePeter Kohl
Oct 26, 2016·Differentiation; Research in Biological Diversity·Milena B FurtadoNadia A Rosenthal
Aug 16, 2016·Archives of Pharmacal Research·Hitoshi Kurose, Supachoke Mangmool
Oct 19, 2016·Nature Communications·Hung X NguyenNenad Bursac
Mar 16, 2018·International Journal of Molecular Sciences·Robert D Johnson, Patrizia Camelliti
Jan 13, 2018·Journal of Cardiovascular Translational Research·Angela W C LeeSteven A Niederer
Jan 30, 2018·Annals of the New York Academy of Sciences·Ashley AzarChristian Sell
Nov 4, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Orly Eva WeissDanny Baranes
Oct 6, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Cristina PogontkeJosé M Pérez-Pomares
Jun 6, 2019·Methods and Protocols·Tania ZagliaMarco Mongillo
Oct 1, 2019·Journal of Cellular and Molecular Medicine·Felicia CarotenutoPaolo Di Nardo
Mar 15, 2020·Heart Failure Reviews·Bianca Olivia Cojan-MinzatLucia Agoston-Coldea
May 28, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Andrea Di MarcoAngel Cequier
Aug 29, 2020·International Journal for Numerical Methods in Biomedical Engineering·Wan N Wan Ab NaimNik A Nik Mohamed
Sep 6, 2018·Nature Reviews. Cardiology·Elvira ForteNadia Rosenthal
Jan 27, 2019·Nature Reviews. Cardiology·Jeffrey J SaucermanJeffrey H Omens
Oct 17, 2019·Ocular Immunology and Inflammation·Li-Fong SeetTina T Wong
Aug 4, 2016·Clinical Medicine Insights. Cardiology·Adam J Connolly, Martin J Bishop
Nov 5, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Ganesh V HaladeKevin A Ingle
Oct 8, 2020·GeroScience·Jan Frohlich, Manlio Vinciguerra
Jan 7, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Eike M WülfersHannah E Fürniss
Mar 23, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Fatemeh CheginiMartin Weiser
Jul 22, 2018·Progress in Biophysics and Molecular Biology·F Cavallini, M Tarantola
Aug 14, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Zohreh VarastehWolfgang A Weber
Jun 1, 2021·Frontiers in Cell and Developmental Biology·Ernesto Marín-SedeñoAdrián Ruiz-Villalba

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