The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation

Cell Death and Differentiation
C BattistelliC Cicchini

Abstract

The expression of the long noncoding RNA HOTAIR (HOX Transcript Antisense Intergenic RNA) is largely deregulated in epithelial cancers and positively correlates with poor prognosis and progression of hepatocellular carcinoma and gastrointestinal cancers. Furthermore, functional studies revealed a pivotal role for HOTAIR in the epithelial-to-mesenchymal transition, as this RNA is causal for the repressive activity of the master factor SNAIL on epithelial genes. Despite the proven oncogenic role of HOTAIR, its transcriptional regulation is still poorly understood. Here hepatocyte nuclear factor 4-α (HNF4α), as inducer of epithelial differentiation, was demonstrated to directly repress HOTAIR transcription in the mesenchymal-to epithelial transition. Mechanistically, HNF4α was found to cause the release of a chromatin loop on HOTAIR regulatory elements thus exerting an enhancer-blocking activity.

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Citations

Dec 29, 2018·Journal of Clinical Medicine·Alice Conigliaro, Carla Cicchini
Jun 20, 2019·Journal of Cellular Physiology·Xiuling ShangRongguo Yu
Oct 16, 2019·Journal of Cellular Physiology·Dezhi Huang, Yugang Jiang
Jan 29, 2020·Journal of Receptor and Signal Transduction Research·Peng LiQiuyun Tu
May 29, 2020·Journal of Receptor and Signal Transduction Research·Nan ZhengDongkai Shan
Jun 26, 2020·Journal of Receptor and Signal Transduction Research·David Mui, Ying Zhang
May 9, 2019·Journal of Cellular Physiology·Xiaowei LiYongbin Ding
Jun 5, 2020·Journal of Receptor and Signal Transduction Research·Zengjun XieLiang Zhao
Nov 10, 2020·Drug Discovery Today·Wesam AliCecilia Battistelli
Jan 7, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Taruna RajagopalNageswara Rao Dunna
Dec 18, 2020·Frontiers in Genetics·América Ramírez-ColmeneroSelene L Fernandez-Valverde
May 22, 2020·ACS Medicinal Chemistry Letters·Annalisa RomanelliSergio Valente

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Methods Mentioned

BETA
transfection
electrophoresis
immunoprecipitation
ChIP

Software Mentioned

MatInspector Professional
MatInspector

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