The local environment orchestrates mucosal decidual macrophage differentiation and substantially inhibits HIV-1 replication

Mucosal Immunology
H El CostaElisabeth Menu

Abstract

Macrophages from the decidua basalis (dM), the main uterine mucosa during pregnancy, are weakly permissive to HIV-1 infection. Here, we investigated the mechanisms underlying this natural control. We show, by using freshly purified decidual macrophages and ex vivo human decidual explants, that the local decidual environment influences dM differentiation and naturally protects these cells from HIV-1 infection. Interferon (IFN)-γ, present in the decidual tissue, contributes to maintenance of the dM phenotype and restricts HIV-1 infection by mechanisms involving the cyclin-dependent kinase inhibitor p21Cip1/Waf1. We also found that activation of Toll-like receptors 7 and 8 expressed by dM reinforces the low permissivity of dM to HIV-1 by restricting viral replication and inducing secretion of cytokines in the decidual environment, including IFN-γ, that shape dM plasticity. A major challenge for HIV-1 eradication is to control infection of tissue-resident macrophages in the female reproductive tract. Our findings provide clues to the development of novel strategies to prevent HIV-1 macrophage infection.

References

Nov 6, 2007·Advances in Immunology·Jamie R Schoenborn, Christopher B Wilson
Sep 24, 2009·Experimental Hematology·Jaehyup Kim, Peiman Hematti
Sep 22, 2010·Nature Immunology·Subhra K Biswas, Alberto Mantovani
Dec 2, 2010·Proceedings of the National Academy of Sciences of the United States of America·Francesca BelloraCristina Bottino
Jan 18, 2011·Nature Immunology·Thomas KrausgruberIrina A Udalova
Jan 13, 2012·American Journal of Reproductive Immunology : AJRI·Theresa JosephGustavo F Doncel
Jan 17, 2012·BMC Infectious Diseases·Hua NianHong Shang
Mar 2, 2012·The Journal of Clinical Investigation·Antonio Sica, Alberto Mantovani
Oct 26, 2012·The Journal of Pathology·Alberto MantovaniMassimo Locati
Apr 18, 2013·PLoS Pathogens·Johan SiewieraNabila Jabrane-Ferrat
Sep 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Letizia LombardelliMarie-Pierre Piccinni
Oct 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Awatef AllouchGianfranco Pancino
Mar 29, 2014·F1000prime Reports·Fernando O Martinez, Siamon Gordon
May 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Awatef AllouchGianfranco Pancino

❮ Previous
Next ❯

Citations

Oct 21, 2019·Immunology·Leticia MoninVictoria Male
Jul 23, 2019·Current Immunology Reviews·Barbara L Shacklett
Oct 21, 2016·Scientific Reports·Hicham El CostaNabila Jabrane-Ferrat
Oct 27, 2020·Frontiers in Immunology·Emily F CornishThomas McDonnell
Apr 27, 2021·Frontiers in Microbiology·Chynna M HendricksMario Stevenson
Aug 10, 2021·Frontiers in Medicine·Ana EspinoNabila Jabrane-Ferrat

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.