The local hypothalamic-pituitary-adrenal axis in cultured human dermal papilla cells

BMC Molecular and Cell Biology
Eun Young LeeJi Hyung Chung

Abstract

Stress is an important cause of skin disease, including hair loss. The hormonal response to stress is due to the HPA axis, which comprises hormones such as corticotropin releasing factor (CRF), adrenocorticotropic hormone (ACTH), and cortisol. Many reports have shown that CRF, a crucial stress hormone, inhibits hair growth and induces hair loss. However, the underlying mechanisms are still unclear. The aim of this study was to examine the effect of CRF on human dermal papilla cells (DPCs) as well as hair follicles and to investigate whether the HPA axis was established in cultured human DPCs. CRF inhibited hair shaft elongation and induced early catagen transition in human hair follicles. Hair follicle cells, both human DPCs and human ORSCs, expressed CRF and its receptors and responded to CRF. CRF inhibited the proliferation of human DPCs through cell cycle arrest at G2/M phase and induced the accumulation of reactive oxygen species (ROS). Anagen-related cytokine levels were downregulated in CRF-treated human DPCs. Interestingly, increases in proopiomelanocortin (POMC), ACTH, and cortisol were induced by CRF in human DPCs, and antagonists for the CRF receptor blocked the effects of this hormone. The results of this study showe...Continue Reading

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Citations

Apr 4, 2021·International Journal of Molecular Sciences·Mika Yamanaka-TakaichiDaisuke Tsuruta

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Methods Mentioned

BETA
flow cytometry
ELISA
fluorescence microscopy
PCR
electrophoresis

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