The local physicochemical environment conditions the proinflammatory response of endothelial cells and thus modulates leukocyte recruitment

FEBS Letters
G B NashG Ed Rainger

Abstract

The locations at which vascular endothelial cells recruit leukocytes during physiological or pathological inflammatory responses are influenced by direct effects of local haemodynamics on leukocyte adhesion. However, the expression of genes by endothelial cells, and their ability to respond to inflammatory cytokines also depend on the flow forces to which they are exposed. In addition, cells of the underlying stroma can modify the phenotype and responsiveness of endothelial cells, and hence their ability to recruit leukocytes. Thus, endothelial cells are plastic in their responses, and we hypothesise that the pattern of recruitment of leukocytes to tissues is critically dependent on the variable modulation of the endothelium by the local physicochemical microenvironment.

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Citations

Jan 13, 2005·Rheumatology·Christopher D BuckleyKarim Raza
May 30, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sahithi J KuraviCaroline O S Savage
Apr 15, 2014·Cardiovascular Research·Sophie Van LinthoutCarsten Tschöpe
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Jan 10, 2012·Journal of Leukocyte Biology·Helen M McGettrickGerard B Nash
Sep 12, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nicolas DumontJérôme Frenette
Nov 14, 2018·Nature Reviews. Rheumatology·Stephanie G DakinChristopher D Buckley
Jun 19, 2021·Frontiers in Immunology·Abbey LightfootAsif J Iqbal

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