PMID: 8943769Oct 1, 1996Paper

The localisation and characterisation of insulin-like growth factor-I receptors and the investigation of melatonin receptors on the hair follicles of seasonal and non-seasonal fibre-producing goats

The Journal of Endocrinology
P DicksL M Williams

Abstract

To define the hormonal influences that are directly involved in the hair follicle cycles of animals with differing patterns of fibre growth and moulting, we have investigated the possible presence of IGF-I and melatonin receptors on the dermis and hair follicles of cashmere and Angora goats, sampled in February. March and June, using quantitative in vitro autoradiography. The presence of IGF-I receptors in the dermis of both breeds of goat was determined using cryostat sections incubated with 50 pM 125I-labelled IGF-I in the presence or absence of 50 nM IGF-I. Sections of the growing tip of deep antlers concerning the cartilaginous zone, a tissue known to contain high concentrations of specific IGF-I receptors, were used as a positive control. As the production of antler velvet uniquely involves the generation of hair follicles de novo, the presence of IGF-I receptors in the velvet-producing region was also investigated. In both breeds of goat, specific 125I-IGF-I binding was localised over the inner and outer root sheath, the matrix, the germinal matrix, the dermal papilla and the sebaceous glands and satisfied the basic kinetic criteria considered to be representative of a specific IGF-I receptor. Analysis of saturation isoth...Continue Reading

Citations

Mar 20, 1998·Comparative Biochemistry and Physiology. Part A, Physiology·A J NixonA J Pearson
Nov 25, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·G A Lincoln, M Richardson
Feb 11, 1999·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·J RoseW Foster
Aug 21, 2008·International Journal of Cosmetic Science·D J Tobin
Jan 29, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrzej SlominskiDesmond J Tobin
Dec 15, 2007·Journal of Pineal Research·Tobias W FischerRalf Paus

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