The localization and release of substance P and calcitonin gene-related peptide at nerve fibre endings in rat cutaneous nerve neuroma.

Brain Research
D M WhiteM Zimmermann

Abstract

This study uses radiological and immunocytochemical techniques to investigate the localization, content, transport and release of substance P- and calcitonin gene-related peptide-like immunoreactivity (SP-LI and CGRP-LI, respectively) in nerve fibre endings in 1-, 3- and 5-week-old cutaneous nerve neuromas. Neuromas were induced by ligating and transecting the saphenous nerve in anaesthetized Sprague-Dawley rats. The content of both neuropeptides in 3-week-old saphenous nerve neuroma was significantly reduced compared to that in normal saphenous nerve. At 5 weeks the levels of the peptides in the neuromas had returned to normal but remained reduced in the nerve just proximal to the neuroma. Following a 24-h ligation of the nerve proximal to 3-week-old neuromas there was a diminished immunocytochemical staining for SP-LI and CGRP-LI both proximal and distal to the ligature when compared to that seen at ligations of normal nerves. This indicates a decreased transport of the neuropeptides both to and from the 3-week-old neuromas. The density of neuropeptide staining at ligatures of nerves with 5 week or older neuromas had increased, but still remained less than that seen at ligations of normal nerve. Both a basal and a bradykinin-...Continue Reading

Citations

Jan 13, 2009·Der Nervenarzt·S Lanz, C Maihöfner
Aug 1, 1993·Neuroscience·J FrisénK Fried
Oct 1, 1992·The British Journal of Dermatology·F Abadía MolinaJ M Polak
Mar 1, 1993·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T YamashitaA I King
Jun 16, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Florian T NickelChristian Maihöfner

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