The localization of [3H]-desipramine in central nerve terminals studied with electron microscope autoradiography and subcellular fractionation

Experientia
Z YavinD Samuel

Abstract

The cellular and subcellular distribution of [3H]-desipramine (DMI) in rat brain was studied by electron microscope (EM) autoradiography and by subcellular fractionation. A considerable proportion of label was found to be bound to the membranes of presynaptic nerve terminals, as well as to sites inside those terminals.

References

Dec 1, 1977·Japanese Journal of Pharmacology·R Ishitani, T Iwamoto
Mar 23, 1978·Nature·P D Kanof, P Greengard
Sep 15, 1978·European Journal of Pharmacology·Z YavinD Samuel
Mar 15, 1975·Biochemical Pharmacology·P F HuntJ P Raynaud
Sep 14, 1971·Biochimica Et Biophysica Acta·L S WolfeG Gombos

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