The localization of nerve growth factor-like immunoreactivity in the adult rat basal forebrain and hippocampal formation

The Journal of Comparative Neurology
J M ConnerM Manthorpe

Abstract

The role of nerve growth factor (NGF) as a target derived neurotrophic agent for specific cell populations in the peripheral nervous system has been well documented and much evidence suggests that NGF may serve a similar neurotrophic role in the CNS supporting the cholinergic neurons of the basal forebrain. Previous attempts to localize NGF by immunocytochemical methods, however, have not yielded evidence confirming the regional distribution expected based upon reported levels of extractable NGF. In the present study, affinity purified polyclonal antibodies to beta-NGF and a modified immunohistochemical protocol were used to demonstrate specific NGF-like immunoreactivity in the adult rat hippocampal formation and basal forebrain. In the hippocampal formation, NGF-like immunoreactivity was localized primarily within the hilus of the dentate gyrus and within stratum lucidum of the CA3 and CA2 hippocampal subfields. Staining appeared to be associated with cell processes and was similar to the reported distribution of mossy fibers suggesting that granule cells may either serve as a primary source of hippocampal NGF or that mossy fibers selectively accumulate NGF produced by other cell populations. In the basal forebrain, NGF-like i...Continue Reading

References

Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Dec 31, 1993·Brain Research·Z C PengM Bentivoglio
Dec 4, 2003·Neurobiology of Aging·Kuei-Cheng LimH J Federoff
Jan 30, 2002·Trends in Neurosciences·Ole IsacsonAnn Charlotte Granholm
Jun 6, 2003·Progress in Neurobiology·Volkmar LessmannMarzia Malcangio
Jan 6, 2000·Progress in Neurobiology·K OjikaN Matsukawa
Jun 5, 1999·Brain Research Bulletin·M QuartuM Del Fiacco
May 6, 1998·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S Rossner
Mar 26, 2002·Autonomic Neuroscience : Basic & Clinical·K A Crutcher
Sep 28, 1998·The European Journal of Neuroscience·Michael D KawajaJ P Julien
Aug 24, 1999·The European Journal of Neuroscience·M CaleoL Maffei
Oct 1, 1994·Journal of Neurotrauma·S Varon, J M Conner
Sep 1, 1995·The European Journal of Neuroscience·M M Dugich-DjordjevicF Hefti
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·T DebeirA C Cuello
Jan 15, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael S RafiiRaymond T Bartus
Aug 1, 1994·Molecular Neurobiology·D P Kuffler
Apr 2, 2011·The Journal of Comparative Neurology·Michael D KawajaMargaret Fahnestock
Mar 22, 2005·Brain Research·Zhen-Guo LiAnders A F Sima
May 17, 2005·Experimental Neurology·Susan H BoraVassilis E Koliatsos

Citations

Jan 1, 1991·Brain Research. Molecular Brain Research·C GallP J Isackson
May 1, 1987·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C J FredericksonG Danscher
Dec 1, 1989·Brain Research. Molecular Brain Research·R B GibbsD W Pfaff
Oct 17, 1986·Science·T H LargeL F Reichardt
Jan 1, 1984·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D J Hazen-Martin, J A Simson

Related Concepts

Establishment and Maintenance of Localization
Immunoreactivity
August Rats
Neurons
Nerve Growth Factor
Peripheral Nervous System
Cell Process Structure
Basal Nucleus of Meynert
Immunocytochemistry
Neurite Outgrowth Factors

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.