PMID: 6988269Jan 1, 1980Paper

The location of VIP in the pancreas of man and rat

Diabetologia
A E BishopS R Bloom

Abstract

VIP has powerful stimulatory effects on both endocrine and exocrine pancreas but its localisation within the gland has not been established. In this study, human pancreas was obtained fresh at surgery (eleven) or within four hours of death (seven). The pancreas was also removed from rats (twenty-two). Immunocytochemical staining showed VIP to be present in fine nerve fibres in all areas of the pancreas. Many fibres were seen in the exocrine pancreas, running between the acini, and around ducts and blood vessels. In addition, dense networks of fibres were observed forming meshes around islets and occasional ganglia were found containing immunoreactive cell bodies. In general, there were fewer VIP fibres in the rat pancreas than in the human, but overall distribution was identical. The mean VIP content of whole human pancreatic tissue was 42 +/- 10 pmol/g wet weight (38 +/- 9 pmol/g in head, 49 +/- 6 pmol/g in body and 42 +/- 11 pmol/g in tail). Whole rat pancreatic tissue contained 28 +/- 7 pmol/g wet weight while preparations of isolated islets were found to contain 374 +/- 30 pmol/g. It is possible that the heavy VIP innervation of the islets described here indicates a role in the regulation of islet hormone release.

References

Jan 1, 1979·Acta Physiologica Scandinavica·J J HolstJ Fahrenkrug
Oct 22, 1977·Histochemistry·L I Larsson
Jun 29, 1978·Nature·J WhartonA G Pearse
May 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L I LarssonE Solcia
Jan 1, 1977·Scandinavian Journal of Gastroenterology·O B Schaffalitzky de MuckadellK B Lauritsen
Mar 2, 1978·Histochemistry·F SundlerO Schaffalitzky de Muckadell
Mar 1, 1978·Life Sciences·L I LarssonO B Schaffalitzky de Muckadell
Sep 5, 1978·Cell and Tissue Research·R BuffaE Solcia
Nov 1, 1978·Gut·S J Mitchell, S R Bloom
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L I LarssonJ R Rehfeld
Sep 30, 1977·Science·L I LarssonO B Schaffalitzky de Muckadell
Mar 1, 1975·The Histochemical Journal·A G Pearse, J M Polak
Aug 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J P PetraliL A Sternberger
Jun 1, 1968·The Biochemical Journal·S L Howell, K W Taylor
Apr 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R C Graham, M J Karnovsky

❮ Previous
Next ❯

Citations

Jun 1, 1997·Microscopy Research and Technique·T Ushiki, S Watanabe
Jun 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A L KirchgessnerM D Gershon
Jul 1, 1992·Diabetes/metabolism Reviews·W Creutzfeldt, M Nauck
Dec 4, 1990·European Journal of Pharmacology·S Karlsson, B Ahrén
Oct 1, 1983·Journal of the Autonomic Nervous System·P H Smith, B J Davis
Oct 1, 1983·Journal of the Autonomic Nervous System·T W Schwartz
Sep 1, 1992·Journal of the Autonomic Nervous System·C SalakijI Nagatsu
Jan 14, 1995·Brain Research. Developmental Brain Research·T TharakanM D Gershon
Jan 1, 1991·Regulatory Peptides·B Ahrén, B Falck
Jan 1, 1983·Acta histochemica·F AmentaF Vatrella
Aug 1, 1981·Lancet·J M PolakS R Bloom
Jul 6, 2000·Peptides·S Persson-SjögrenI B Täljedal
May 1, 1997·Journal of Physiology, Paris·K TakeuchiH Kobayashi
Aug 5, 2000·Anatomia, histologia, embryologia·T MyojinJ Yamada
Feb 1, 1987·The Proceedings of the Nutrition Society·D R Matthews, A Clark
Feb 1, 1996·British Journal of Pharmacology·G BertrandM M Loubatières-Mariani
Sep 27, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Rayner Rodriguez-Diaz, Alejandro Caicedo
Mar 22, 1991·The Journal of Comparative Neurology·A L Kirchgessner, J E Pintar
Sep 4, 2015·Journal of Cellular Physiology·Eliana S Di CairanoCarla Perego
Jun 15, 2007·Peptides·Maria Sörhede Winzell, Bo Ahrén
Jan 8, 2013·ChemMedChem·Chandralal M Hewage, Kalyana C Venneti
Mar 1, 1981·The American Journal of Medicine·M A PfeiferD Porte
Apr 11, 2007·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Marcin Bartłomiej Arciszewski, Anna Zacharko-Siembida
Jul 5, 2011·Cell Metabolism·Rayner Rodriguez-DiazAlejandro Caicedo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.