PMID: 18406797May 1, 1997Paper

The logic of signaling from the cell surface to the nucleus

Trends in Endocrinology and Metabolism : TEM
N D HorsemanA Ralescu

Abstract

The apparent imprecisions in the signal transduction mechanisms that couple specific hormone receptors to predictable nuclear transcription events have raised many issues for both biology and medicine. In this article, a fuzzy logic model is proposed to provide a means of formally describing signal transduction systems and making predictions about the effects of various combinations of inputs. The fuzzy logic model may provide opportunities mathematically to describe regulatory ensembles that are too complex to describe by conventional models. In addition, the nature of "fuzzy variables" provides insight into the paradoxes that underlie both imprecision and predictability in signal transduction.

References

Mar 1, 1991·Molecular and Cellular Biology·J L MeinkothJ R Feramisco
Oct 17, 1991·Nature·B J PulvererJ R Woodgett
Jan 1, 1990·Annual Review of Cell Biology·L J Ransone, I M Verma
Oct 14, 1994·Biochemical and Biophysical Research Communications·A KubotaY Seino
Jan 1, 1995·Annual Review of Biochemistry·C Schindler, J E Darnell
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L M GravesE G Krebs
Nov 12, 1993·Science·S J Cook, F McCormick
May 5, 1995·Biochemical and Biophysical Research Communications·P J Coffer, W Kruijer
Jun 16, 1995·Cell·M P PeppelenboschJ L Bos
Jan 1, 1994·Progress in Growth Factor Research·A L Mui, A Miyajima
Dec 16, 1993·Nature·M S Boguski, F McCormick
Jan 28, 1994·Cell·T KishimotoS Akira
Sep 23, 1993·Biochimica Et Biophysica Acta·K A Lee, N Masson
Mar 1, 1993·Cytokine·D Cosman
Aug 1, 1993·Trends in Cell Biology·D J Glass, G D Yancopoulos

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Citations

Dec 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S Krauss, M D Brand

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