The logistic score: a criterion for hypothermia after perinatal asphyxia?

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Jean-Louis Wayenberg

Abstract

To identify during the first hour of life the asphyxiated term neonates who further develop moderate or severe neonatal encephalopathy. In 75 asphyxiated term infants, we measured postnatal arterial base deficit (BD30), assigned an early neurological score (ENS) according to their level of consciousness, respiration pattern and neonatal reflexes at 30 min of life and calculated the logistic score (LS) = (0.33 x BD30) - ENS. The receiver operating characteristics (ROC) methodology was applied to analyze the ability of the LS to correctly classify patients into two groups: normal or mild encephalopathy (60 patients) versus moderate or severe encephalopathy (15 patients). The area under the ROC curve of the LS for moderate or severe encephalopathy (+/- standard error) was 94.4 +/- 3.6%. At the threshold value of 1.2, the LS provided 87.5% sensitivity and 73.7% positive predictive value (PPV). The PPV of LS reaches 100% for a value >3.2, but this threshold allowed only 53.3% sensitivity. The LS is predictive of the neonatal neurological evolution after birth asphyxia and may help to select the high risk patients who are potential candidates for hypothermia therapy.

References

Aug 1, 1975·Anesthesiology·G A Gregory
Jul 1, 1992·Archives of Disease in Childhood·N Marlow
Apr 1, 1991·American Journal of Diseases of Children·E W NelsonP L McCarthy
Jan 1, 1991·Journal of Clinical Epidemiology·D L SimelD B Matchar
Jan 1, 1990·American Journal of Obstetrics and Gynecology·R J PortmanG B Merenstein
Sep 1, 1989·American Journal of Obstetrics and Gynecology·L C GilstrapB B Little
May 1, 1983·Acta paediatrica Scandinavica·U ErganderR Zetterström
Jan 1, 1981·The Journal of Pediatrics·N N FinerK L Peters
Sep 1, 1995·Archives of Disease in Childhood. Fetal and Neonatal Edition·P EkenL S de Vries
Jan 1, 1995·Archives of Disease in Childhood. Fetal and Neonatal Edition·L Hellström-WestasN W Svenningsen
Jun 22, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·M C ToetL S de Vries
Jan 17, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Sachin ShahJohn Smyth
Nov 3, 2004·Pediatric Neurology·Hasan TekgulSarenur Gokben
Dec 21, 2004·Pediatric Neurology·Dorothea J EicherJerome Y Yager
Feb 11, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Ajay J TalatiHenrietta S Bada
Jul 29, 2005·Annals of Neurology·Daqing MaMervyn Maze
Aug 23, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·N MarlowE S Draper
Oct 14, 2005·The New England Journal of Medicine·Seetha ShankaranUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Dec 13, 2005·Biology of the Neonate·Katharina RuetzlerMichael Obladen
Jan 5, 2006·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jean-Louis Wayenberg
Jun 13, 2006·Developmental Science·Michelle de HaanMortimer Mishkin
Jul 5, 2006·Archives of Pediatrics & Adolescent Medicine·Prakesh S ShahMax Perlman
Sep 26, 2006·Pediatric Neurology·Katarina LindströmElisabeth Fernell
Oct 24, 2006·Archives of Disease in Childhood. Fetal and Neonatal Edition·F F Gonzalez, S P Miller
Nov 3, 2006·Pediatrics·Namasivayam AmbalavananUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Sep 11, 2007·Seminars in Fetal & Neonatal Medicine·Janet M RennieNicola J Robertson
Oct 3, 2007·Archives of Pediatrics & Adolescent Medicine·Prakesh S ShahMax Perlman
Nov 21, 2007·Neonatology·Gilberto CompagnoniFabio Mosca
Dec 9, 2008·Archives of Disease in Childhood. Fetal and Neonatal Edition·D AzzopardiUNKNOWN Steering Group and TOBY Cooling Register participants

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