The Long and Winding Road to Gamma-Amino-Butyric Acid as Neurotransmitter

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
Massimo Avoli, Krešimir Krnjević

Abstract

This review centers on the discoveries made during more than six decades of neuroscience research on the role of gamma-amino-butyric acid (GABA) as neurotransmitter. In doing so, special emphasis is directed to the significant involvement of Canadian scientists in these advances. Starting with the early studies that established GABA as an inhibitory neurotransmitter at central synapses, we summarize the results pointing at the GABA receptor as a drug target as well as more recent evidence showing that GABAA receptor signaling plays a surprisingly active role in neuronal network synchronization, both during development and in the adult brain. Finally, we briefly address the involvement of GABA in neurological conditions that encompass epileptic disorders and mental retardation.

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Citations

Feb 20, 2018·Frontiers in Plant Science·Petronia Carillo
Feb 23, 2019·CNS Drugs·Ariela FriederKristina M Deligiannidis
Nov 3, 2020·Antonie van Leeuwenhoek·Eman Zakaria Gomaa
Dec 29, 2020·Molecular Genetics and Metabolism·Trevor O KirbyK Michael Gibson
Aug 26, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Maria Grazia ZizzoRosa Serio
Oct 16, 2021·Experimental Biology and Medicine·Debanjan BhattacharyaSoma Sengupta
Nov 13, 2021·Canadian Journal of Physiology and Pharmacology·Yehezkel Ben-AriMassimo Avoli

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