The long-lasting post-stimulation inhibitory effects of bladder activity induced by posterior tibial nerve stimulation in unanesthetized rats.

Scientific Reports
Eunkyoung ParkKyu-Sung Lee

Abstract

Tibial nerve stimulation (TNS) is one of the neuromodulation methods used to treat an overactive bladder (OAB). However, the treatment mechanism is not accurately understood owing to significant differences in the results obtained from animal and clinical studies. Thus, this study was aimed to confirm the response of bladder activity to the different stimulation frequencies and to observe the duration of prolonged post-stimulation inhibitory effects following TNS. This study used unanesthetized rats to provide a closer approximation of the clinical setting and evaluated the changes in bladder activity in response to 30 min of TNS at different frequencies. Moreover, we observed the long-term changes of post-stimulation inhibitory effects. Our results showed that bladder response was immediately inhibited after 30 min of 10 Hz TNS, whereas it was excited at 50 Hz TNS. We also used the implantable stimulator to observe a change in duration of the prolonged post-stimulation inhibitory effects of the TNS and found large discrepancies in the time that the inhibitory effect lasted after stimulation between individual animals. This study provides important evidence that can be used to understand the neurophysiological mechanisms underl...Continue Reading

References

Dec 1, 1991·The American Journal of Physiology·D C RudyJ D McAndrew
Jan 1, 1983·The Journal of Urology·E J McGuireB Lytton
Nov 3, 1994·European Journal of Pharmacology·M YoshiyamaW C De Groat
Dec 22, 1999·Neurourology and Urodynamics·S Matsuura, J W Downie
Feb 22, 2002·Neurourology and Urodynamics·Paul AbramsUNKNOWN Standardisation Sub-committee of the International Continence Society
Sep 29, 2004·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Karin S CoyneTimothy L Hunt
Sep 2, 2006·The Journal of Physiology·Joseph W BoggsWarren M Grill
Jan 30, 2007·Current Medical Research and Opinion·Roger R Dmochowski, Diane K Newman
Feb 17, 2007·Neurourology and Urodynamics·Changfeng TaiJames R Roppolo
Sep 14, 2007·Expert Review of Medical Devices·Michael R van Balken
Dec 14, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chih-Wei PengWarren M Grill
Apr 24, 2008·Journal of Neural Engineering·Chih-Wei PengWarren M Grill
May 21, 2008·Nature Reviews. Neuroscience·Clare J FowlerWilliam C de Groat
Nov 17, 2009·The Journal of Urology·Scott A MacDiarmidBrian A Feagins
Apr 17, 2010·BJU International·Changfeng TaiWilliam C de Groat
Jul 3, 2010·Digestive Diseases and Sciences·Patrick D MeekBora Gumustop
Aug 3, 2010·Lower Urinary Tract Symptoms·Minoru MiyazatoKimio Sugaya
Nov 26, 2010·American Journal of Physiology. Renal Physiology·Changfeng TaiWilliam C de Groat
May 24, 2011·The Journal of Urology·Changfeng TaiWilliam C de Groat
Nov 4, 2011·American Journal of Physiology. Renal Physiology·Xin SuDwight E Nelson
Jan 1, 2000·Neuromodulation : Journal of the International Neuromodulation Society·M B Chancellor, E J Chartier-Kastler
Jan 13, 2012·American Journal of Physiology. Renal Physiology·Changfeng TaiWilliam C de Groat
Mar 14, 2012·International Urogynecology Journal·Pamela J LevinCindy L Amundsen
Aug 10, 2012·American Journal of Physiology. Renal Physiology·Xin SuDwight E Nelson
Dec 1, 2012·American Journal of Physiology. Renal Physiology·Mitsuharu YoshiyamaWilliam C de Groat
Jul 3, 2013·Nature Reviews. Urology·Jamie BartleyKenneth Peters
Feb 4, 2014·Contemporary Clinical Trials·Cindy L AmundsenSusie Meikle
Feb 14, 2014·American Journal of Physiology. Renal Physiology·Zhiying XiaoChangfeng Tai
Apr 20, 2014·Physiological Reports·Yosuke MatsutaChangfeng Tai
Nov 28, 2014·American Journal of Physiology. Renal Physiology·Mario Kovacevic, Paul B Yoo
Jan 16, 2015·Comprehensive Physiology·William C de GroatNaoki Yoshimura
Sep 12, 2015·The Journal of Pharmacology and Experimental Therapeutics·Zhaocun ZhangChangfeng Tai
Dec 10, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Valentín ManríquezG Alessandro Digesu
Dec 23, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Mahipal ChoudharyEls van Asselt
Feb 3, 2016·SpringerPlus·Mahipal ChoudharyEls van Asselt
Mar 18, 2016·The Journal of Bone and Joint Surgery. American Volume·Mary Claire ManskeSandra E Klein

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

LabChart
MATLAB

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.