Abstract
Papillary thyroid cancer (PTC) is the most common histotype of Thyroid cancer (TC). Here, we detected the differentially expressed lncRNAs in tumor tissues and non-tumor tissues of PTC patients by lncRNA microarrays, and explored the function and molecular mechanisms of lncRNAs in the pathogenesis of PTC using a PTC cell line. CCK-8 assay, colony formation assay and EdU assay were used to detect the cell viability. Flow Cytometry was used to detect the cell cycle and apoptosis. Transwell and scratch assay were used to detect the cell motility. CCK-8 assay, colony formation assay and EdU assay revealed that lncRNAs (ENST00000537266 and ENST00000426615) could inhibit cell proliferation. Cell cycle analysis showed that cell proportion was statistically significant increased in G1 phase and decreased in S phase and G2 phase in Si-266 transfected TPC-1 cells. In addition, a noteworthy increase of cell proportion in G1 phase accompanied by a decrease in S phase and unchanged G2 phase in Si-615 transfected TPC-1 cells were also observed. Meanwhile, transwell and scratch assay showed that ENST00000426615 could inhibit the cell motility while ENST00000537266 could not. Our results showed that lncRNAs (ENST00000426615 and ENST00000537266...Continue Reading
Citations
Nov 1, 2016·Thyroid : Official Journal of the American Thyroid Association·Qiangfeng WangFusheng Wu
Aug 24, 2016·Scientific Reports·Hui ZhuMing Yang
Mar 2, 2017·Journal of Clinical Laboratory Analysis·Zhen-Lin NieShu-Kui Wang
Jun 2, 2018·International Journal of Immunopathology and Pharmacology·Hong ZhangNingyi Jiang
Nov 18, 2017·Endocrine-related Cancer·Avaniyapuram Kannan MuruganAli S Alzahrani
Feb 26, 2019·Oncology Research and Treatment·Mohammad-Reza Mahmoudian-SaniGholam-Reza Mobini
Sep 6, 2019·Journal of Biological Engineering·Yiming DengZhongrong Miao
Nov 14, 2019·Genes·Berta Luzón-ToroSalud Borrego
Oct 21, 2017·Oncotarget·Xianxiu GeLin Miao
Jan 18, 2018·Oncotarget·Xiliang WangLisha Mou
Jan 8, 2020·Journal of Clinical Laboratory Analysis·Runqi ChenFuguo Tian
Jul 16, 2019·Journal of Biological Engineering·Chun-Wang ZhangGuo-Qing Li
Aug 18, 2020·Anatomical Sciences Education·Dale E Fournier, Adam M R Groh
Nov 15, 2018·Journal of Experimental & Clinical Cancer Research : CR·Wen BiJiewu Zhang
Nov 24, 2019·Experimental & Molecular Medicine·Jun-Cheng GuoLiu Zhuo
Oct 24, 2019·Cancer Biotherapy & Radiopharmaceuticals·Gang WangYing Jin
May 12, 2017·Scientific Reports·Lucas GoedertEnilza Maria Espreafico
Nov 7, 2019·Bioscience Reports·Zheng-Lin WangZhi-Long Ai
Aug 7, 2019·Current Opinion in Endocrinology, Diabetes, and Obesity·Mahsa Sedaghati, Electron Kebebew
Sep 27, 2019·Journal of Cellular Physiology·Duo-Ping WangJian Xu
Oct 16, 2019·Oncology Letters·Li ChenLing-Jie Zhang
Apr 4, 2019·BMC Cancer·Bin SongDawei Hou
Apr 1, 2021·Seminars in Cancer Biology·Rui-Xin LinHong Zhang
Aug 10, 2021·Journal of Gastroenterology and Hepatology·Jinjun YeXing Bao