The Long Non-Coding RNA MIR503HG Enhances Proliferation of Human ALK-Negative Anaplastic Large-Cell Lymphoma

International Journal of Molecular Sciences
Po-Shuan HuangKwang-Huei Lin

Abstract

Anaplastic lymphoma kinase (ALK)-negative anaplastic large-cell lymphoma (ALCL) is a rare type of highly malignant, non-Hodgkin lymphoma. Currently, only a few gene rearrangements have been linked to ALK-negative ALCL progression. However, the specific molecular mechanisms underlying the growth of ALK-negative ALCL tumors remain unclear. Here, we investigated aberrantly expressed, long non-coding RNAs (lncRNAs) in ALK-negative ALCL and assessed their potential biological function. MIR503HG (miR-503 host gene) was highly expressed in ALK-negative cell lines and was significantly upregulated in tumors in mice formed from ALK-negative ALCL cell lines. Depletion of MIR503HG suppressed tumor cell proliferation in vivo and in vitro; conversely, its overexpression enhanced tumor cell growth. MIR503HG-induced proliferation was mediated by the induction of microRNA-503 (miR-503) and suppression of Smurf2, resulting in stabilization of the tumor growth factor-β receptor (TGFBR) and enhanced tumor cell growth. Collectively, these findings support a potential role for MIR503HG in cancer cell proliferation through the miR-503/Smurf2/TGFBR axis and indicate that MIR503HG is a potential marker in ALK-negative ALCL.

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Citations

May 6, 2019·International Journal of Molecular Sciences·Steffen FuchsFabienne Meggetto
May 8, 2019·Journal of Cellular and Molecular Medicine·Jia FuBin Xiong
Sep 19, 2020·Wiley Interdisciplinary Reviews. RNA·Qinyu SunKannanganattu V Prasanth
Dec 3, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Xu Cao, Qiu-Ling Fan
Mar 1, 2020·European Journal of Pharmacology·Soudeh Ghafouri-FardMohammad Taheri
Mar 12, 2021·Circulation Research·João P MonteiroAndrew H Baker

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Methods Mentioned

BETA
ubiquitination
Xenograft
electrophoresis
transfecting

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