The Long Non-coding RNA NRIR Drives IFN-Response in Monocytes: Implication for Systemic Sclerosis

Frontiers in Immunology
Barbara MariottiFlavia Bazzoni

Abstract

TLR4 activation initiates a signaling cascade leading to the production of type I IFNs and of the downstream IFN-stimulated genes (ISGs). Recently, a number of IFN-induced long non-coding RNAs (lncRNAs) that feed-back regulate the IFN response have been identified. Dysregulation of this process, collectively known as the "Interferon (IFN) Response," represents a common molecular basis in the development of autoimmune and autoinflammatory disorders. Concurrently, alteration of lncRNA profile has been described in several type I IFN-driven autoimmune diseases. In particular, both TLR activation and the upregulation of ISGs in peripheral blood mononuclear cells have been identified as possible contributors to the pathogenesis of systemic sclerosis (SSc), a connective tissue disease characterized by vascular abnormalities, immune activation, and fibrosis. However, hitherto, a potential link between specific lncRNA and the presence of a type I IFN signature remains unclear in SSc. In this study, we identified, by RNA sequencing, a group of lncRNAs related to the IFN and anti-viral response consistently modulated in a type I IFN-dependent manner in human monocytes in response to TLR4 activation by LPS. Remarkably, these lncRNAs were ...Continue Reading

References

Mar 16, 2002·Nature Immunology·Vladimir ToshchakovStefanie N Vogel
Jan 31, 2004·Seminars in Immunology·Kiyoshi Takeda, Shizuo Akira
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicola TamassiaMarco A Cassatella
May 26, 2009·Nucleic Acids Research·Jing ChenAnil G Jegga
May 18, 2010·Annals of the Rheumatic Diseases·Maija-Leena ElorantaLars Rönnblom
Oct 1, 2011·Drug Discovery Today·Murali M YallapuSubhash C Chauhan
Jul 18, 2012·The Open Rheumatology Journal·Robert Lafyatis, Alessandra Farina
Nov 8, 2012·Nature Structural & Molecular Biology·Sònia Guil, Manel Esteller
Aug 30, 2013·Expert Reviews in Molecular Medicine·Marzena CiechomskaSteven O'Reilly
Nov 14, 2013·Clinical Science·Steven O'Reilly
Dec 24, 2013·Nature Reviews. Immunology·Lionel B Ivashkiv, Laura T Donlin
Feb 22, 2014·Current Opinion in Immunology·Katherine A Fitzgerald, Daniel R Caffrey
Apr 18, 2014·Science Translational Medicine·Swati BhattacharyyaJohn Varga
Aug 13, 2014·Trends in Immunology·James A Heward, Mark A Lindsay
Aug 15, 2014·Nucleic Acids Research·Hiroto KambaraSaba Valadkhan
Nov 5, 2014·Frontiers in Immunology·Anna StachurskaSebo Withoff
Nov 29, 2014·Frontiers in Immunology·Katsutoshi Imamura, Nobuyoshi Akimitsu
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders
Jan 22, 2015·Current Rheumatology Reports·Swati Bhattacharyya, John Varga
Mar 18, 2015·Immunology and Cell Biology·Albert D YuKevin V Morris
Jun 13, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·José Luiz Marques-RochaAmelia Marti
Jun 20, 2015·Journal of Immunology Research·Keshav Raj SigdelYanLin Zhang
Aug 28, 2016·The Journal of Allergy and Clinical Immunology·Federica CalzettiMarco A Cassatella
Jan 7, 2017·Respiratory Research·Jong-Uk LeeChoon-Sik Park
Mar 16, 2017·Clinical Rheumatology·Alain LescoatPatrick Jégo
May 30, 2017·International Journal of Inflammation·Mark Farrugia, Byron Baron
Sep 1, 2017·Arthritis & Rheumatology·Marta CossuTimothy R D J Radstake
Nov 12, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Tiago CarvalheiroArtur Paiva
May 16, 2018·Annals of the Rheumatic Diseases·Clara CrescioliCristina Antinozzi

❮ Previous
Next ❯

Citations

Apr 24, 2019·Non-coding RNA·Marina R Hadjicharalambous, Mark A Lindsay
Sep 18, 2020·Molecular Diagnosis & Therapy·Vincent M TutinoJames N Jarvis
Jun 12, 2020·Therapeutic Advances in Musculoskeletal Disease·Bianca Saveria FiorettoMarco Matucci-Cerinic
Jun 21, 2020·Annals of the Rheumatic Diseases·Lorenzo BerettaUNKNOWN PRECISESADS Flow Cytometry study group
Dec 10, 2019·Current Rheumatology Reports·Pei-Suen Tsou
Nov 4, 2020·RNA Biology·Katharina Walther, Leon N Schulte
Feb 13, 2021·International Journal of Molecular Sciences·Marco BocchettiAlessia Maria Cossu
Aug 4, 2020·Journal of Translational Autoimmunity·Yaoyao Zou, Hanshi Xu
May 21, 2021·Transplant Immunology·Yao TengQiuling Wu
Aug 5, 2021·Journal of Cell Communication and Signaling·Anastasiya MuntyanuElena Netchiporouk
Sep 5, 2021·Nature Reviews. Rheumatology·Pei-Suen TsouSteven O'Reilly

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE123532
GSE124075
GSE122459

Methods Mentioned

BETA
FCS
electrophoresis
PCR
RNA-seq
transfection

Software Mentioned

Bio
Ensemble
LinReg PCR
Ensembl
WGCNA R - package
HTSeq
count
TopHat
Oligo Explorer
xPONENT

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.