The Long Noncoding RNA HOTAIR in Breast Cancer: Does Autophagy Play a Role?

International Journal of Molecular Sciences
Elżbieta PawłowskaJanusz Blasiak

Abstract

HOTAIR (HOX transcript antisense RNA) plays a critical role in chromatin dynamics through the interaction with histone modifiers resulting in transcriptional gene silencing. The promoter of the HOTAIR gene contains multiple estrogen response elements (EREs) and is transcriptionally activated by estradiol in estrogen receptor-positive breast cancer cells. HOTAIR competes with BRCA1, a critical protein in breast cancer and is a critical regulator of genes involved in epithelial-to-mesenchymal transition. It mediates an oncogenic action of c-Myc, essential for breast carcinogenesis. The carcinogenic action of HOTAIR was confirmed in breast cancer stem-like cells, in which it was essential for self-renewal and proliferation. Several miRNAs regulate the expression of HOTAIR and HOTAIR interacts with many miRNAs to support cancer transformation. Many studies point at miR-34a as a major component of HOTAIR-miRNAs-cancer cross-talk. The most important role of HOTAIR can be attributed to cancer progression as its overexpression stimulates invasion and metastasis. HOTAIR can regulate autophagy, important for breast cancer cells survival, through the interaction with miRNAs specific for autophagy genes and directly with these genes. The r...Continue Reading

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Citations

Apr 18, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Qiu Hong RuiZhen Yu Cai
Dec 5, 2019·Cancer Investigation·Sheng-Hong ShiZhi-Gang Zhuang
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Jan 17, 2020·Journal of Cellular Biochemistry·Chunjue YuanYunbao Pan
May 14, 2020·Cancers·Monica CantileGerardo Botti
Aug 18, 2018·International Journal of Genomics·Tao ZengLiang Gao
Feb 23, 2019·Cancer Research·Yueyuan ZhengJian Ren
Mar 20, 2021·Seminars in Cancer Biology·Rui ZhangSuling Liu
Jul 22, 2021·Journal of Developmental Biology·Elena L Novikova, Milana A Kulakova
Sep 16, 2020·Cell Death & Disease·Lingxia LiuJun Lu
Nov 17, 2021·Archives of Gynecology and Obstetrics·Daoping ZhangMeirong Peng

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Methods Mentioned

BETA
histone acetylation
ubiquitination

Software Mentioned

HOTAIR

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