The long pentraxin 3 is a soluble and cell-associated component of the human semen

International Journal of Andrology
Andrea DoniCecilia Garlanda

Abstract

The long pentraxin 3 (PTX3) is a multifunctional soluble pattern recognition receptor, involved in several processes ranging from innate resistance and inflammation to clearance of apoptotic cells and organization of hyaluronic acid-rich extracellular matrices. PTX3 is also a novel marker in several pathological conditions of infectious, inflammatory, or autoimmune origin. This study was designed to assess whether PTX3 is expressed in the male reproductive tract and whether PTX3 interacts with human spermatozoa influencing their function. Here we show for the first time by immunohistochemistry that PTX3 is expressed in the male genital tract in perivascular connective tissue, in endothelial cells, in the interstitium, and in the cytoplasm of prostatic epithelial glandular cells; PTX3 was detectable in seminal plasma in variable levels, which correlated with the percentage of normal spermatozoa. Moreover, PTX3 binds to spermatozoa, in particular with immotile cells, localizing in the neck and in the subacrosomial region. Finally, recombinant PTX3 did not interfere with sperm motility.

References

May 20, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M Eisenbach, I Tur-Kaspa
Dec 22, 1999·Clinical and Experimental Immunology·M M LuchettiA Gabrielli
Jul 20, 2002·Lancet·Johannes L H Evers
Mar 21, 2003·European Journal of Immunology·Alma J NautaAnja Roos
Oct 13, 2004·Circulation·Roberto LatiniUNKNOWN Lipid Assessment Trial Italian Network (LATIN) Investigators
Mar 18, 2005·Annual Review of Immunology·Cecilia GarlandaAlberto Mantovani
Jun 25, 2005·Journal of Medical Virology·Albert T A MairuhuEric C M van Gorp
Jul 19, 2005·Molecular Immunology·Claire L HarrisB Paul Morgan
Dec 22, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Monica MuratoriElisabetta Baldi
Feb 16, 2006·Journal of Leukocyte Biology·Barbara BottazziAlberto Mantovani
Mar 7, 2006·Journal of the Society for Gynecologic Investigation·Alessio PaffoniCecilia Garlanda
May 2, 2006·American Journal of Obstetrics and Gynecology·Irene CetinAlberto Mantovani

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Citations

Nov 11, 2009·Journal of Reproductive Immunology·Cecilia GarlandaFederica Moalli
Oct 13, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Annika SonessonJohan Malm

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