The long pentraxin PTX3 promotes fibrocyte differentiation

PloS One
Darrell PillingRichard H Gomer

Abstract

Monocyte-derived, fibroblast-like cells called fibrocytes are associated with fibrotic lesions. The plasma protein serum amyloid P component (SAP; also known as pentraxin-2, PTX2) inhibits fibrocyte differentiation in vitro, and injections of SAP inhibit fibrosis in vivo. SAP is a member of the pentraxin family of proteins that includes C-reactive protein (CRP; PTX1) and pentraxin-3 (PTX3). All three pentraxins are associated with fibrosis, but only SAP and CRP have been studied for their effects on fibrocyte differentiation. We find that compared to SAP and CRP, PTX3 promotes human and murine fibrocyte differentiation. The effect of PTX3 is dependent on FcγRI. In competition studies, the fibrocyte-inhibitory activity of SAP is dominant over PTX3. Binding competition studies indicate that SAP and PTX3 bind human FcγRI at different sites. In murine models of lung fibrosis, PTX3 is present in fibrotic areas, and the PTX3 distribution is associated with collagen deposition. In lung tissue from pulmonary fibrosis patients, PTX3 has a widespread distribution, both in unaffected tissue and in fibrotic lesions, whereas SAP is restricted to areas adjacent to vessels, and absent from fibrotic areas. These data suggest that the relative ...Continue Reading

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Citations

Sep 10, 2015·Proceedings of the National Academy of Sciences of the United States of America·Darrell PillingRichard H Gomer
Mar 17, 2016·Trends in Molecular Medicine·Adam J ByrneClare M Lloyd
Feb 28, 2016·Journal of Hepatology·Barbara BottazziAlberto Mantovani
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Jun 9, 2020·Frontiers in Physiology·Andrea FariniYvan Torrente
Nov 22, 2018·Frontiers in Immunology·Darrell Pilling, Richard H Gomer
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Mar 9, 2021·Frontiers in Immunology·Federica MaccarinelliRoberto Ronca
Jul 3, 2021·Frontiers in Immunology·Dorra Elhaj MahmoudLilia Laadhar
Aug 22, 2021·Journal of Endocrinological Investigation·E J Neag, T J Smith

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Methods Mentioned

BETA
flow cytometry
FCS
glycosylation

Software Mentioned

Prism
ImageJ
GraphPad

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