The long-term behavior of lightweight and heavyweight meshes used to repair abdominal wall defects is determined by the host tissue repair process provoked by the mesh

Surgery
G PascualJuan M Bellón

Abstract

Although heavyweight (HW) or lightweight (LW) polypropylene (PP) meshes are widely used for hernia repair, other alternatives have recently appeared. They have the same large-pore structure yet are composed of polytetrafluoroethylene (PTFE). This study compares the long-term (3 and 6 months) behavior of meshes of different pore size (HW compared with LW) and composition (PP compared with PTFE). Partial defects were created in the lateral wall of the abdomen in New Zealand White rabbits and then repaired by the use of a HW or LW PP mesh or a new monofilament, large-pore PTFE mesh (Infinit). At 90 and 180 days after implantation, tissue incorporation, gene and protein expression of neocollagens (reverse transcription-polymerase chain reaction/immunofluorescence), macrophage response (immunohistochemistry), and biomechanical strength were determined. Shrinkage was measured at 90 days. All three meshes induced good host tissue ingrowth, yet the macrophage response was significantly greater in the PTFE implants (P < .05). Collagen 1/3 mRNA levels failed to vary at 90 days yet in the longer term, the LW meshes showed the reduced genetic expression of both collagens (P < .05) accompanied by increased neocollagen deposition, indicating...Continue Reading

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Citations

Dec 29, 2013·Hernia : the Journal of Hernias and Abdominal Wall Surgery·C G Pereira-lucenaM M Linhares
Jul 19, 2014·Hernia : the Journal of Hernias and Abdominal Wall Surgery·J JerabekI Capov
Jan 25, 2013·Hernia : the Journal of Hernias and Abdominal Wall Surgery·L ZogbiM R M Trindade
Feb 26, 2016·Journal of the Mechanical Behavior of Biomedical Materials·B CalvoJ M Bellón
Jul 3, 2013·Computer Methods in Biomechanics and Biomedical Engineering·Izabela Lubowiecka
Jul 9, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Federico VozziClaudio Domenici
Aug 12, 2017·Neurourology and Urodynamics·Mahshid VashaghianJan-Paul Roovers
Sep 28, 2018·Expert Review of Medical Devices·Uwe Klinge, Bernd Klosterhalfen
Jun 3, 2021·Materials·Marta RodríguezJuan Manuel Bellón

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