The long-term course of hepatitis C after kidney transplantation

Transplantation
V KliemU Frei

Abstract

Patients with chronic hepatitis run the risk of developing progressive liver disease during immunosuppressive therapy after kidney transplantation. To determine the impact of chronic hepatitis C on morbidity and mortality we analyzed 162 anti-HCV positive of 1241 renal-grafted patients (prevalence 13.1%; 84.9% HCV RNA positive) regularly surveyed in our outpatient clinic between 1992 and 1994. The mean age at transplantation was 44.5 (6-69) years, and follow-up after grafting was 7.4 (0.1-23.9) years. The immunosuppressive regimen and frequency of rejection episodes in HCV-infected patients were comparable to the total population. Only 4.3% (5/117) of the anti-HCV positive, HBV negative patients living with functioning grafts developed a markedly compromised liver function. Fifteen (9.3%) of the HCV-infected patients died, but none suffered from posthepatitic cirrhosis. An additional retrospective analysis of causes of death after transplantation prior to 1992 revealed that liver disease had only been responsible for 2% of the deaths (7 of 324) in the HBsAg negative population (n= 1901). In contrast, the predominant cause of death in the HBsAg positive population (n=76) was posthepatitic cirrhosis in 58% (15 of 26). Thus, kidne...Continue Reading

References

Sep 10, 1977·Lancet·G Modena, I Portioli
Sep 1, 1979·Annals of Internal Medicine·A J WareB Combes
Aug 15, 1991·The New England Journal of Medicine·B J PereiraA S Levey
Oct 1, 1991·Kidney International·E PonzJ Andreu
Oct 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K KiyosawaR H Purcell
Oct 18, 1990·The New England Journal of Medicine·J I EstebanR Esteban
Mar 1, 1988·Transplantation·C ToussaintP Vereerstraeten
Nov 1, 1985·Seminars in Liver Disease·R VenkataramananR J Ptachcinski
Nov 1, 1985·Kidney International·M R WeirN L Tilney
Sep 24, 1966·Lancet·E A Friedman, G E Thomson
Sep 12, 1966·Minerva medica·E Wildhirt
Jul 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J WareT Parker
Dec 1, 1982·Transplantation·R L KirkmanN L Tilney
Dec 1, 1981·Transplantation·M P LaQuagliaR H Rubin
Apr 1, 1982·Annals of Internal Medicine·J H HoofnagleJ Costa
Feb 1, 1981·American Journal of Epidemiology·W SzmunessE J Harley
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F ValderrábanoN P Mallick
Dec 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C CarameloM P Garrón
Jan 1, 1994·Kidney International·D RothJ Miller
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·B J Pereira
Jun 24, 1993·The New England Journal of Medicine·H TsukumaH Yamazaki
Dec 1, 1994·The Clinical Investigator·V KliemU Frei
Jun 1, 1995·The New England Journal of Medicine·M J TongR L Co
Feb 1, 1994·Kidney International·E GoffinC van Ypersele de Strihou
Jun 1, 1993·Transplantation·R W EvansF P Sanfilippo
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M A Mansell

❮ Previous
Next ❯

Citations

Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P MathurinM O Bitker
Dec 20, 2000·Transplantation Proceedings·Y KokadoA Okuyama
Mar 27, 2001·Transplantation Proceedings·G MosconiS Stefoni
Mar 27, 2001·Transplantation Proceedings·V MasG de Boccardo
Dec 21, 2002·Transplantation Proceedings·J N BoletisC Stavropoulos-Giokas
Sep 2, 1998·Transplantation Proceedings·J M Morales
Jun 11, 2003·Journal of Gastroenterology and Hepatology·Behzad EinollahiSeyed Moayed Alavian
Oct 10, 2002·Kidney International·Claudio PonticelliAntonio Tarantino
Dec 10, 1998·Transplantation·H WedemeyerK H Boeker
Apr 8, 1998·Current Opinion in Nephrology and Hypertension·J M MoralesJ L Rodicio
Apr 3, 2004·Gastroentérologie Clinique Et Biologique·Nassim KamarLaurent Alric
Oct 31, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F FabriziC Ponticelli
Jan 9, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ihab M MahmoudMohamed A Sobh
Sep 4, 2004·Clinical Transplantation·Siren SezerMehmet Haberal
Aug 15, 2008·Reviews in Medical Virology·Seyed Mohammadmehdi Hosseini MoghaddamNahid Arjmand Kermani
Dec 8, 2007·Reviews in Medical Virology·Seema Baid-AgrawalNina Tolkoff-Rubin
May 24, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Patrizia BurraMarco Senzolo
Jul 15, 2004·Transplantation Proceedings·R C Botero
Sep 1, 1999·Rheumatic Diseases Clinics of North America·D VassilopoulosR M Strauss
Jul 13, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·S J Hadziyannis, D Vassilopoulos
Jul 15, 2011·International Journal of Nephrology·Marco CarboneJames Neuberger
Jul 31, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M EspinosaP Aljama
Jun 28, 2003·The International Journal of Artificial Organs·F FabriziP Martin
Sep 28, 2002·Transplantation·Edward Gane, Helen Pilmore
Sep 20, 2002·Journal of the American Society of Nephrology : JASN·Emilio RamosWilliam E Harmon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.