The long-term development of non-motor problems after STN-DBS

Acta Neurologica Scandinavica
B LilleengJ P Larsen

Abstract

Stimulation of the subthalamic nucleus (STN-DBS) is an established treatment with long-term beneficial effects on motor symptoms in patients with Parkinson's disease (PD). The long-term development of non-motor problems after STN-DBS is not fully understood. In this study, we have studied how non-motor problems develop in patients with and without STN-DBS. We collected data from a prospectively followed cohort of patients that had been operated with STN-DBS 6-9 years before final examination and compared our findings to the longitudinal development of non-motor problems in a non-operated, comparable reference population. In general, the non-motor problems of advanced PD seem to develop independently of treatment with STN-DBS. We found that depressions do not worsen after STN-DBS, and the Montgomery and Aasberg Depression Rating Scale score in operated patients was substantially reduced from pre-operatively to post-operatively. Further, fatigue may represent an important unrecognized side effect of long-term stimulation, as fatigue was found to increase rapidly in operated patients already a year after surgery and continued to increase trough the 6- to 9-year follow-up. The non-motor problems of advanced PD seem to develop indep...Continue Reading

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Citations

Jul 27, 2015·Parkinsonism & Related Disorders·K J PeallM A J Tijssen
Jun 11, 2016·Acta Neurologica Scandinavica·A YlikoskiM Partinen
Nov 5, 2016·Parkinsonism & Related Disorders·Lukas EugsterW M Michael Schuepbach
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May 7, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Stefanie Theresa JostUNKNOWN EUROPAR and the International Parkinson and Movement Disorders Society Non-Motor Parkinson's Disease Study Group.
Oct 22, 2020·NPJ Parkinson's Disease·Silje BjerknesMathias Toft
Dec 18, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Thomas J C ZoonRob M A de Bie
Oct 15, 2020·Journal of Neural Engineering·Matteo VissaniAlberto Mazzoni

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