PMID: 3744192May 1, 1986Paper

The long-term effect of dietary administration of refined sugars and sugar alcohols on plasma biochemistry, urine biochemistry and tissue histology in mice given a limited degree of dietary self-selection

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
N PoteznyR A Conyers

Abstract

A prototype animal feeding model is described in which mice were meal-fed a balanced diet but were given free access to water (controls) or 20% (w/v) solutions of glucose, sucrose, fructose, xylitol or sorbitol. Under these conditions it was found that the provision of an alternative energy source, in the form of a refined carbohydrate, produced marked effects on total energy intake, mouse cube (i.e. balanced energy) intake and body weight. There were also changes in the metabolic states of the animals as assessed by serum levels of glucose, urea and cholesterol, plasma levels of lactate and D-3-hydroxybutyrate, and urinary excretion of urea and oxalate. Histological examinations of tissue indicated that the sucrose-fed mice had a tendency to suffer from acute congestion of the lungs and liver steatosis. Given a limited degree of dietary self-selection it appears that mice are more likely to be at risk of excessive food consumption and obesity when given glucose- or sucrose-containing diets than they are when fructose-, xylitol- or sorbitol-containing diets are given.

References

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Feb 13, 2001·Vaccine·M UhariT Kontiokari

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Citations

May 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M RofeR A Conyers
May 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K M MacKenzieJ Stanley
Apr 24, 2014·Journal of the Science of Food and Agriculture·Zarina MushtaqMuhammad Umair Arshad

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