The long-term efficacy of STN vs GPi deep brain stimulation for Parkinson disease: A meta-analysis

Medicine
Lilei PengLigang Chen

Abstract

This meta-analysis assessed the long-term efficacy of deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus interna (GPi) for Parkinson disease (PD). PubMed, Cochrane Library, and Clinical Trials databases were searched. Outcomes were unified Parkinson disease rating scale section (UPDRS) III off-medication score, Parkinson's disease questionnaire: 39 activities of daily living (PDQ-39 ADL) score, and levodopa-equivalent dosage after DBS. During the off-medication state, pooled weighted mean difference (WMD) of UPDRS III score was .69 (95% confidence interval [CI] = -1.77 to 3.16, P = .58). In subgroup analysis, WMD of UPDRS III off-medication scores from baseline to 2 years and 3 years post-DBS were -.61 (95% CI = -2.97 to 1.75, P = .61) and 2.59 (95% CI = -2.30 to 7.47, P = .30). Pooled WMD of changes in tremor, rigidity, and gait scores were 1.12 (95% CI = -0.05 to 2.28, P = .06), 1.22 (95% CI = -0.51 to 2.94, P = .17) and .37 (95% CI = -0.13 to 0.87, P = .15), respectively. After DBS, pooled WMD of PDQ-39 ADL and LED were -3.36 (95% CI = -6.36 to -0.36, P = .03) and 194.89 (95% CI = 113.16 to 276.63, P < .001). STN-DBS and GPi-DBS improve motor function and activities of daily living for PD. Diff...Continue Reading

References

Sep 29, 2001·The New England Journal of Medicine·UNKNOWN Deep-Brain Stimulation for Parkinson's Disease Study GroupA E Lang
Jun 20, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·UNKNOWN Movement Disorder Society Task Force on Rating Scales for Parkinson's Disease
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Jun 3, 2004·Annals of Neurology·Jens VolkmannHans-Joachim Freund
Jun 8, 2004·Current Opinion in Neurology·Ubaldo Bonuccelli
Jun 25, 2005·Brain : a Journal of Neurology·M C Rodriguez-OrozN Van Blercom
Apr 29, 2008·Purinergic Signalling·Marek CieślakAndrzej Wojtczak
Jun 4, 2010·The New England Journal of Medicine·Kenneth A FollettUNKNOWN CSP 468 Study Group
Jun 23, 2012·Neurology·Frances M WeaverUNKNOWN CSP 468 Study Group
Jan 30, 2015·Annals of Neurology·Maya KatzUNKNOWN CSP 468 study group
Jan 29, 2016·Neurology·Vincent J J OdekerkenUNKNOWN NSTAPS study group

❮ Previous
Next ❯

Citations

Dec 21, 2018·The European Journal of Neuroscience·David Papo
Dec 16, 2020·Neurology India·Richa Tripathi, Milind Deogaonkar
Jan 31, 2021·Neurochemistry International·Sarah JarrinEilís Dowd
Jul 20, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Fiona Permezel
Nov 27, 2021·Seminars in Neurology·Andrea Lee, Harini Sarva
Dec 4, 2021·CNS Neuroscience & Therapeutics·Jose Antonio Camacho-CondeZafar U Khan

❮ Previous
Next ❯

Software Mentioned

RevMan

Related Concepts

Related Feeds

Brain-Computer Interface

A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.