PMID: 38623Jun 1, 1979

The long-term hypotensive effect of timolol maleate compared with the effect of pilocarpine in simple and capsular glaucoma

Acta Ophthalmologica
P J Airaksinen

Abstract

The long-term intraocular pressure (IOP) lowering effect of a beta-adrenergic blocking agent, timolol maleate, in topical administration was compared with the effect of pilocarpine on simple and capsular glaucoma by means of diurnal pressure curves during a six-month follow-up. In simple glaucoma timolol was more effective than pilocarpine in lowering IOP. In the follow-up a significant but not marked increase of the IOP was observed. In capsular glaucoma timolol was not effective enough, but when it was co-administered with miotics the IOP lowering effect was better than with either substance alone. Timolol induced no accomodative myopia, miosis, reduction of tear flow or other side effects. It increased the outflow facility in simple glaucoma but not in capsular glaucoma. During the trial, the anterior chamber depth increased while the corneal thickness remained unchanged. Four out of the six eyes included in a previous report of secondary glaucoma due to chronic uveitis are still, after one year of therapy, controlled with timolol.

References

May 1, 1977·The British Journal of Ophthalmology·I A MackieJ M Pescod
Oct 1, 1978·Acta Ophthalmologica·E Kerty, I Hørven
Jun 7, 1975·British Medical Journal·P J Holt, E Waddington
Apr 22, 1977·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·G K KrieglsteinW Leydhecker
Apr 1, 1977·Archives of Ophthalmology·T J Zimmerman, H E Kaufman
Feb 1, 1978·Acta Ophthalmologica·R RitchS M Podos
Jul 1, 1978·American Journal of Ophthalmology·W P BogerD Pavan-Langston
Jun 19, 1978·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·F E RosE L Greve
Jun 1, 1978·Archives of Ophthalmology·R L RadiusM E Langham
May 1, 1976·The British Journal of Ophthalmology·A H RahiP Wright

Citations

Jan 1, 1982·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·K K TakkiO Valle
Jan 1, 1982·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·P J AiraksinenA Klemetti
Feb 27, 1999·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·S BurgalassiM F Saettone
Dec 1, 1993·Acta Ophthalmologica·G Tezel, T H Tezel
Jul 3, 2018·Journal of Glaucoma·Mohamed S Sayed, Richard K Lee
Dec 1, 1980·Acta Ophthalmologica·B Calissendorff, N Marén
Aug 30, 2014·International Ophthalmology Clinics·Helen L Kornmann, Steven J Gedde
Dec 1, 1979·The British Journal of Ophthalmology·P J AiraksinenE A Jaanio
Dec 11, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Ian S Douglas, David M Cockburn

Related Concepts

Adrenergic beta-Antagonists
Drug Evaluation
Glaucoma
Physiologic Intraocular Pressure
Miotic Effect
Ophthalmic Solution
Salagen
Propanolamines
Timoptol

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