The long-term management of pancreas transplantation

Transplantation
Martin L MaiThomas Gonwa

Abstract

Diabetes mellitus (DM) is a major health problem worldwide, which affects 18.2 million individuals (6.3% of the population) in the United States. Currently, the prevalence of Type 1 DM in the United States is estimated to be 1,000,000 individuals, and 30,000 new cases are diagnosed each year. In addition to end-stage renal disease (ESRD), DM is associated with blindness, accelerated atherosclerosis, dyslipidemia, cardio- and cerebrovascular disease, amputation, poor quality of life, and overall lifespan reduction. It accounts for more than 160,000 deaths per year in the United States alone. In 2002, the annual national direct and indirect costs of Types 1 and 2 DM exceeded $130 billion, which included hospital and physician care, laboratory tests, pharmaceutical products, and patient workdays lost because of disability or premature death. Hyperglycemia alone or in concert with hypertension is the primary factor influencing the development of major diabetic complications. From 1990 to 2001, the number of existing ESRD cases to DM increased by more than 300%, while the rate per million populations increased from 167% to 491%. The number is expected to grow 10-fold by 2030 to 1.3 million accounting for 60% of ESRD population. To d...Continue Reading

References

Jan 29, 1976·The New England Journal of Medicine·M E LevinL V Avioli
Sep 1, 1992·Transplantation·A O GaberD Hathaway
Aug 22, 1991·The New England Journal of Medicine·B A JulianL D Quarles
Oct 31, 1991·The New England Journal of Medicine·H KatzR Rizza
Sep 1, 1991·Calcified Tissue International·R Bouillon
Aug 1, 1991·Diabetologia·A KönigsrainerR Margreiter
Aug 1, 1991·Diabetologia·A ScheiderR Landgraf
Jan 1, 1989·Diabetes·D E SutherlandR K Sibley
Jan 28, 1988·The New England Journal of Medicine·R C RamsayJ S Najarian
Feb 1, 1986·Annals of Surgery·U J HesseJ S Najarian
Aug 31, 1974·British Medical Journal·L S IbelsA G Sheil
Jan 1, 1981·Bulletin de la Société belge d'ophtalmologie·S Riaskoff
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·H Klinkmann, J Vienken
Jul 1, 1995·Calcified Tissue International·M A ValeroF Hawkins
Mar 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C LumbrerasC V Paya
Dec 1, 1994·Archives of Surgery·J E EverettD L Dunn
Aug 1, 1994·American Journal of Public Health·G L Lu-YaoE S Fisher
Jun 23, 1994·The New England Journal of Medicine·J A Kraut, J W Coburn
Jul 1, 1993·Kidney International·Y PeiD Sherrard
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Feb 1, 1993·Kidney International·D J SherrardG V Segre
Jun 27, 1996·Transplantation·B J NankivellR D Allen
Aug 1, 1996·Muscle & Nerve·X NavarroD E Sutherland
Jan 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S Epstein
Sep 19, 1996·The New England Journal of Medicine·G TydénJ Bolinder

❮ Previous
Next ❯

Citations

Feb 9, 2011·Diabetes Technology & Therapeutics·Cyrus JahansouzKenneth L Brayman
Nov 7, 2007·Endocrinology and Metabolism Clinics of North America·Gerald S Lipshutz, Alan H Wilkinson
Sep 25, 2007·Transplantation Proceedings·J NicolauL Fernández-Cruz
Aug 30, 2008·The Mount Sinai Journal of Medicine, New York·Susan M Lerner
Nov 17, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Richard HummelJens G Brockmann
Mar 15, 2014·Acta Cirúrgica Brasileira·Rogério Renato PerezAdriano Miziara Gonzalez
Jan 22, 2009·Transplantation·Fu L LuanMatthias Kretzler
Jul 12, 2019·Current Diabetes Reports·Karim Hamaoui, Vassilios Papalois
Jul 14, 2017·Clinical Diabetes and Endocrinology·Marcio W Lauria, Antonio Ribeiro-Oliveira

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.