The long-term natural history of trachomatous trichiasis in the Gambia

Investigative Ophthalmology & Visual Science
Matthew J BurtonR L Bailey

Abstract

Trachoma is the leading infectious cause of blindness. However, there are few data on the natural history of trachomatous trichiasis to guide program planning or that investigate its pathogenesis. A cohort of Gambians with trichiasis in one or both eyes who had declined surgery was observed. Clinical examinations were performed at baseline and 4 years later. Conjunctival swab samples were collected for Chlamydia trachomatis PCR and bacteriology. One hundred fifty-four people were examined at baseline and 4 years later (241 nonsurgical eyes). At baseline 124 (52%) eyes had major trichiasis (5+ lashes), 75 (31%) minor trichiasis (1-4 lashes), and 42 (17%) no trichiasis. By 4 years, trichiasis had developed in 12 (29%) of 42 previously unaffected eyes. Minor trichiasis progressed to major in 28 (37%) of 75 eyes. New corneal opacification more commonly developed in eyes that had major (10%) compared to minor (5%) trichiasis at baseline. Bacterial infection was common (23%), becoming more frequent with increasing trichiasis. C. trachomatis infection was rare (1%). Conjunctival inflammation was common (29%) and was associated with progressive trichiasis and corneal opacification. Trichiasis progressed in the long-term in this environ...Continue Reading

Citations

Jul 31, 2007·Transactions of the Royal Society of Tropical Medicine and Hygiene·Jean-François SchémannDenis Malvy
Mar 20, 2008·PLoS Neglected Tropical Diseases·Paul M EmersonFrank O Richards
Dec 3, 2008·PLoS Neglected Tropical Diseases·Nicholas C GrasslyRobin L Bailey
Apr 1, 2009·PLoS Neglected Tropical Diseases·Isobel M BlakeNicholas C Grassly
Jun 17, 2009·PLoS Neglected Tropical Diseases·Manoj GambhirNicholas C Grassly
Dec 3, 2010·PLoS Neglected Tropical Diseases·Abdou AmzaLucienne Bella-Assumpta
Mar 5, 2013·PLoS Neglected Tropical Diseases·Victor H HuMatthew J Burton
Jun 6, 2009·Drugs·Anu A MathewHugh R Taylor
Apr 9, 2010·Tropical Medicine & International Health : TM & IH·Victor H HuDavid C W Mabey
Oct 7, 2011·Ophthalmology·Saul N RajakMatthew J Burton
Aug 3, 2016·PLoS Neglected Tropical Diseases·Athumani M RamadhaniMatthew J Burton
May 25, 2007·The Lancet Infectious Diseases·Manoj GambhirNicholas C Grassly
Mar 15, 2015·PLoS Neglected Tropical Diseases·Esmael HabtamuMatthew J Burton
Nov 26, 2019·PLoS Neglected Tropical Diseases·Rebecca M FlueckigerAnthony W Solomon
May 2, 2019·BMC Infectious Diseases·Rebecca Mann FlueckigerRachel L Pullan
Oct 14, 2008·Ophthalmic Epidemiology·Dereje HabteYared Assefa
May 31, 2018·Investigative Ophthalmology & Visual Science·Victor H HuMatthew J Burton

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