The long-term oral exposure to titanium dioxide impaired immune functions and triggered cytotoxic and genotoxic impacts in rats.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Mohamed M HashemAhmed Bahy-El-Dien

Abstract

Titanium dioxide "TiO2, E171″ is a widely used food additive that exists in various everyday food products all over the world together with vast applications in cosmetics and industry. However, many toxicological aspects particularly following oral exposure still unclear. Hence, this study was planned to examine the effect of oral exposure of male Wistar rats to two doses of TiO2 (20 or 40 mg/kg b.wt.) through oral gavage once daily for 90 consecutive days on the blood components, immunity, cytotoxic, and genotoxic indicators. A dose-dependent leukopenia, eosinophilia, neutrophilia, and thrombocytopenia were noted. Also, the immunoglobins G (IgG) and IgM were significantly elevated in TiO2 treated rats. The phagocytic activities, lysozyme, nitric oxide, and immunoglobulin levels were significantly depleted following TiO2 exposure. A significantly reduced lymphocyte proliferation but elevated LDH activity was prominent in TiO2 treated rats. Different pathological perturbations were observed in both splenic tissue and bone marrow. A marked increase in CD4+ and CD8+ immunolabeling was evident. A significant increase in the comet variables was recorded in response to the exposure of rats to the increasing level of TiO2 at both leve...Continue Reading

References

Mar 1, 1988·Experimental Cell Research·N P SinghE L Schneider
Jun 30, 1985·Toxicology and Applied Pharmacology·K P LeeC F Reinhardt
Jan 29, 2000·Immunology and Cell Biology·J ChinA Mullbacher
Jul 7, 2000·The New England Journal of Medicine·P J Delves, I M Roitt
Apr 24, 2003·Journal of Occupational and Environmental Medicine·Jon P FryzekWilliam J Blot
Nov 6, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Edilberto BermudezJeffrey I Everitt
Jul 29, 2004·Cancer Causes & Control : CCC·Paolo BoffettaElisabete Weiderpass
Feb 3, 2006·Journal of Immunoassay & Immunochemistry·Hyung Sim ChoiChaekyun Kim
Apr 8, 2006·The Lancet Oncology·Robertv BaanUNKNOWN WHO International Agency for Research on Cancer Monograph Working Group
Apr 1, 2008·Experimental Biology and Medicine·Abderrahim NemmarBadreldin H Ali
May 30, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Masanao YokohiraKatsumi Imaida
Dec 11, 2008·Biological Trace Element Research·Huiting LiuFashui Hong
Jan 21, 2012·Environmental Science & Technology·Alex WeirNatalie von Goetz
Apr 5, 2012·Clinical & Developmental Immunology·Rishi Vishal LuckheeramBing Xia
Aug 31, 2012·Radiology and Oncology·Matej SkocajSasa Novak
Oct 16, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Robert R MaronpotShim-Mo Hayashi
Nov 13, 2012·American Journal of Industrial Medicine·Elizabeth D EllisDavid J Girardi
Mar 7, 2014·Toxicology Letters·Zhangjian ChenGuang Jia
Apr 8, 2014·Industrial Health·Gil Soon ChoiEun-Kee Park
Apr 25, 2014·International Journal of Molecular Sciences·Yanyun FuGeyu Liang
May 14, 2014·BioMed Research International·Yasmina M Abd-ElhakimLaila Y Al-Ayadhi
Dec 3, 2014·Research in Veterinary Science·Rong H YinXiao R Han
Mar 5, 2015·Journal of Agricultural and Food Chemistry·Jin-Hee LimSean W Linder
Jun 27, 2015·Regulatory Toxicology and Pharmacology : RTP·Darrell R BoverhofSteve C Gordon
Apr 9, 2016·Journal of Basic and Clinical Pharmacy·Anroop B Nair, Shery Jacob
Jul 28, 2016·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Wafaa A M MohamedSameh M Farouk
Oct 5, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Gihan G Moustafa, Mohamed M A Hussein
Sep 16, 2017·Journal of Food and Drug Analysis·Chutima Matayatsuk Phechkrajang, Surin Yooyong
Sep 1, 2015·Journal of Food and Drug Analysis·Pei-Jia LuDaniel Yang-Chih Shih
Feb 14, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yasmina M Abd-ElhakimSabry M Abd-Elmotal
Jun 3, 2018·Journal of Nanobiotechnology·Hans Christian WinklerHanspeter Naegeli
Jun 8, 2018·Journal of Agricultural and Food Chemistry·Fabio FiordalisoLuisa Diomede
Jul 8, 2018·Environmental Science and Pollution Research International·Khaled Abo-El-SooudAhmed Bahy-El-Dien
Jul 18, 2018·International Immunopharmacology·Khaled Abo-El-SooudAli Q Gab-Allaha
Jul 19, 2018·Journal of Biochemical and Molecular Toxicology·Yasmina M Abd-ElhakimKhaled Abo-El-Sooud
Aug 11, 2018·International Immunopharmacology·Yasmina M Abd-ElhakimHaytham A Ali
Dec 5, 2018·Journal of Agricultural and Food Chemistry·Jin-Hee LimAndrew Fong
Jan 6, 2019·Methods in Molecular Biology·Atish KizhakeyilNavin Kumar Verma
Feb 16, 2019·Toxicological Research·Mohamed Mohammed HashemMona M E Eleiwa

❮ Previous
Next ❯

Citations

May 8, 2020·International Journal of Molecular Medicine·Daniela CalinaAristidis Tsatsakis
Oct 15, 2020·Foods·Ludmila MotelicaEcaterina Andronescu
May 13, 2021·EFSA Journal·UNKNOWN EFSA Panel on Food Additives and Flavourings (FAF)Matthew Wright

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.