The long-term outcomes of epilepsy surgery

PloS One
Midhun MohanUdo Wieshmann

Abstract

Despite modern anti-epileptic drug treatment, approximately 30% of epilepsies remain medically refractory and for these patients, epilepsy surgery may be a treatment option. There have been numerous studies demonstrating good outcome of epilepsy surgery in the short to median term however, there are a limited number of studies looking at the long-term outcomes. The aim of this study was to ascertain the long-term outcome of resective epilepsy surgery in a large neurosurgery hospital in the U.K. This a retrospective analysis of prospectively collected data. We used the 2001 International League Against Epilepsy (ILAE) classification system to classify seizure freedom and Kaplan-Meier survival analysis to estimate the probability of seizure freedom. We included 284 patients who underwent epilepsy surgery (178 anterior temporal lobe resections, 37 selective amygdalohippocampectomies, 33 temporal lesionectomies, 36 extratemporal lesionectomies), and had a prospective median follow-up of 5 years (range 1-27). Kaplan-Meier estimates showed that 47% (95% CI 40-58) remained seizure free (apart from simple partial seizures) at 5 years and 38% (95% CI 31-45) at 10 years after surgery. 74% (95% CI 69-80) had a greater than 50% seizure red...Continue Reading

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Citations

Sep 26, 2019·Frontiers in Molecular Neuroscience·Larissa KrausPawel Fidzinski
Oct 5, 2019·Expert Review of Neurotherapeutics·Jasmina R MilovanovićSrđan Stefanović
Sep 10, 2019·Neuropharmacology·Pavel Klein, Ivana Tyrlikova
Nov 29, 2020·Epilepsy & Behavior : E&B·Benzi M KlugerMark Spitz
Jan 16, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Tamir AvigdorBirgit Frauscher
Dec 3, 2020·Chaos·Leandro JungesJohn R Terry
Feb 16, 2021·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·Jana C DrexlinVeronika M Stein
Jun 2, 2020·Neurosurgery Clinics of North America·Nathaniel D Sisterson, Vasileios Kokkinos
Mar 23, 2021·NMR in Biomedicine·Jullie W PanHoby P Hetherington
Aug 6, 2021·Epilepsy & Behavior : E&B·Jafar Mehvari HabibabadiNasim Tabrizi

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