The long-term prognosis of Guillain-Barré syndrome. Evaluation of prognostic factors including plasma exchange

Acta Neurologica Scandinavica
C VedelerH Nyland

Abstract

Fifty-two patients with Guillain-Barré syndrome (GBS) were re-examined 1-14 years (median 7 years) after the initial onset of symptoms. At the follow-up 38 patients (73%) reported being completely symptom-free. Neurological examination revealed that 11 patients (21%) had motor and 16 patients (31%) had sensory signs, mainly distal in the lower limbs. One patient (2%) had cranial nerve signs. Fifteen patients (29%) had areflexia, generally of the ankle jerks. Severe pareses (high maximal disability grade), long duration of maximal symptoms and recovery were significantly associated with persistent disability. Age, sex, preceding infection, latency between infection and the onset of disease, weakness as an initial symptom, autonomic dysfunction, speed of progression, electro-physiological signs of axonal degeneration, cerebrospinal-fluid protein concentration and treatment with plasma exchange did not significantly influence the disability grade at follow-up.

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Citations

Aug 13, 2005·Journal of Neurology·A BersanoE Nobile-Orazio
Mar 7, 2009·Journal of Neurology·Tiina RekandChristian A Vedeler
Aug 7, 2002·Journal of the Neurological Sciences·Robert A J A M BernsenFrans G A van der Meché
Sep 20, 2000·Ugeskrift for laeger·C Krarup, S Vorstrup
Sep 14, 2007·Disability and Rehabilitation·Sibel Ozbudak Demir, Füsun Köseoğlu
May 7, 2013·Neurologic Clinics·Mazen M Dimachkie, Richard J Barohn
Dec 4, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·B-C ChengC-H Lu
Jan 24, 2007·Muscle & Nerve·Marcel P J GarssenMachiel J Zwarts
Nov 18, 2004·Journal of the Neurological Sciences·Anette ForsbergUNKNOWN Swedish Epidemiological Study Group
Sep 9, 2010·Journal of Child Neurology·Caitlin W HicksManikum Moodley
Aug 22, 2007·American Journal of Physical Medicine & Rehabilitation·Lhassan El MhandiLeonard Féasson
Dec 1, 2017·Annals of Indian Academy of Neurology·Subasree RamakrishnanSunder Periyavan
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Jun 28, 2000·Current Opinion in Neurology·C A Vedeler
Oct 17, 2003·Journal of Medical Biography·Armond S GoldmanFrank C Schmalstieg
May 9, 2003·Neurogenetics·Janardan P Pandey, Christian A Vedeler

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